糖蛋白降解：糖类是关键所在吗？
Glycoprotein degradation: do sugars hold the key?
作者信息
Frigerio L, Lord J M
机构信息
Department of Biological Sciences, University of Warwick, CV4 7AL, Coventry, UK.
出版信息
Curr Biol. 2000 Sep 21;10(18):R674-7. doi: 10.1016/s0960-9822(00)00680-1.
Abstract
Secretory glycoproteins that fail to fold or assemble correctly are retained in the endoplasmic reticulum and eventually degraded. Recent evidence shows that trimming of their N-linked oligosaccharide chains plays a key role in targeting glycoproteins for destruction.
摘要
未能正确折叠或组装的分泌性糖蛋白会滞留在内质网中，最终被降解。最近的证据表明，其N-连接寡糖链的修剪在将糖蛋白靶向破坏中起关键作用。
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