[对牙周病患者针对具核梭杆菌和腐蚀艾肯菌抗体反应的ELISA检测分析]
[Analysis using ELISA test of antibody response to Fusobacterium nucleatum and Eikenella corrodens in subjects with periodontal disease].
作者信息
Gutiérrez J, Guerrero R, Noguerol B, Menéndez M, Liébana J
机构信息
Departamento de Estomatología, Universidades de Granada y Oviedo, Hospital Universitario San Cecilio.
出版信息
Med Clin (Barc). 2000 Jul 1;115(5):176-7. doi: 10.1016/s0025-7753(00)71499-0.
BACKGROUND
To know the synthesis of IgG, IgA, and IgM to Fusobacterium nucleatum and Eikenella corrodens in serum, crevicular liquid and saliva in subjects with periodontal disease, using ELISA test.
PATIENTS AND METHODS
We studied 26 patients with high bias to the disease aged less than 35 years and 30 individuals with comparable age and with scarce bias to the disease.
RESULTS
No differences were found for IgG and IgM titers between the groups, except for IgM to E. corrodens. For IgA, differences were found when the saliva and crevicular liquid were studied for both bacteria, as occurred in serum IgA compared to E. corrodens. In all the cases antibody levels were lower in the patients.
CONCLUSIONS
The lower synthesis of IgM and IgA, fundamentally the latter, to F. nucleatum and E. corrodens in patients with periodontal disease would contribute to the pathogenesis of this illness.
背景
采用酶联免疫吸附测定（ELISA）试验，了解牙周病患者血清、龈沟液和唾液中针对具核梭杆菌和腐蚀艾肯菌的IgG、IgA和IgM的合成情况。
患者与方法
我们研究了26名年龄小于35岁且疾病倾向较高的患者以及30名年龄相仿且疾病倾向较低的个体。
结果
除针对腐蚀艾肯菌的IgM外，两组之间的IgG和IgM滴度未发现差异。对于IgA，在研究唾液和龈沟液中两种细菌时发现了差异，血清中针对腐蚀艾肯菌的IgA情况也是如此。在所有情况下，患者的抗体水平较低。
结论
牙周病患者针对具核梭杆菌和腐蚀艾肯菌的IgM和IgA合成降低，尤其是后者，这可能促成了该疾病的发病机制。
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