Pruthi V K, Kurup V P, Resnick A, Dewullf J A
Faculty of Dentistry, University of Manitoba, Canada.
Indian J Dent Res. 1990 Apr-Sep;2(2-3):158-65.
This study examined the difference between the serum antibody profiles in refractory adult periodontitis patients (group A), and compared to those (group B) who responded well to conventional periodontal treatment. The levels of specific IgG antibody to Actinobacillus actinomycetemcomitans, Bacteroides gingivalis, Fusibacteriumnucleatum, and Eikenella corrodens were assessed in a group of 19 patients (group A) and 11 patients (group B). Specific IgG serum antibody levels were estimated using biotin-avidin linked immunosorbent assay (BALISA). Results indicated that Actinobacillus actinomycetemcomitans, and Bacteroides gingivalis had very high levels of specific circulating antibody in the sera of both groups of patients; whereas, Fusobacterium nucleatum and Eikenella corrodens showed considerable lower levels of antibody than the other two antigens. However, the differences between the two groups with regard to the antibody levels against different bacterial antigens were not statistically significant.
本研究检测了难治性成人牙周炎患者（A组）血清抗体谱的差异，并与对常规牙周治疗反应良好的患者（B组）进行比较。在19例患者（A组）和11例患者（B组）中评估了针对伴放线放线杆菌、牙龈拟杆菌、具核梭杆菌和腐蚀艾肯菌的特异性IgG抗体水平。使用生物素-抗生物素蛋白连接免疫吸附测定法（BALISA）估计特异性IgG血清抗体水平。结果表明，伴放线放线杆菌和牙龈拟杆菌在两组患者血清中的特异性循环抗体水平都非常高；而具核梭杆菌和腐蚀艾肯菌的抗体水平明显低于其他两种抗原。然而，两组在针对不同细菌抗原的抗体水平方面的差异无统计学意义。
