Pérez Carro Ríos A, García Caballero T, Lozano Ramírez A, Arias Santos M D, Soto Varela A, Forteza Vila J, Labella Caballero T
University Complex of Santiago, Department of Otorhinolaryngology, Spain.
Rev Laryngol Otol Rhinol (Bord). 2000;121(2):121-5.
Cell proliferation index is one of the most important factors in assessment of growth and progression of tumours. At present, the most suitable method of determining cell proliferation is by means of immunohistochemical techniques which use the monoclonal anti-body MIB-1 which reacts against Ki-67, a protein released only in the proliferation phases of the cell cycle. In this study, 44 patients diagnosed with squamous cell carcinoma of the larynx were analysed retrospectively and different macroscopic and microscopic parameters were assessed, such as MIB-1 in relation to the current status of the patient. A statistically significant relationship was found between the cell proliferation index, the histological grade of differentiation and the clinical evolution of the illness.
细胞增殖指数是评估肿瘤生长和进展的最重要因素之一。目前，测定细胞增殖最合适的方法是借助免疫组织化学技术，该技术使用与Ki-67反应的单克隆抗体MIB-1，Ki-67是一种仅在细胞周期增殖阶段释放的蛋白质。在本研究中，对44例诊断为喉鳞状细胞癌的患者进行了回顾性分析，并评估了不同的宏观和微观参数，如与患者当前状况相关的MIB-1。发现细胞增殖指数、组织学分化程度与疾病的临床进展之间存在统计学上的显著关系。
