抗供体血清（ADS）和供体细胞对DL-A组织分型同窝幼龄比格犬肾移植存活的影响
Effect of anti-donor serum (ADS) and donor cells on renal allograft survival in DL-A tissue-typed littermate beagles.
作者信息
Jeekel J, Obertop H, Vriesendorp H M, McDicken I, Westbroek D L
出版信息
Transplant Proc. 1975 Sep;7(3):435-8.
The influence of passive and active immunization on kidney allograft survival was tested in littermate beagles differing in one and two DL-A haplotypes. Immunization by treatment of recipients with hyperimmune antidonor serum (ADS) prolonged graft survival only in a few donor-recipient combinations differing in one DL-A haplotype. All ADS batches that were tested in MLC reaction did block this reaction, but no correlation with its in vivo activities was found. Hyperimmunization of recipients with donor lymphoid cells before grafting caused a second-set rejection, whereas one injection with donor blood did so only in 14%, with antibody production and accelerated rejection. A short course of horse antidog lymphocyte serum (HADLS) prolonged kidney graft survival. The addition of intravenously given donor bone-marrow cells to this protocol did not lead to a further increase in graft survival.
在具有一个和两个DL - A单倍型差异的同窝小猎犬中测试了被动免疫和主动免疫对肾移植存活的影响。用超免疫抗供体血清（ADS）治疗受体进行免疫，仅在少数具有一个DL - A单倍型差异的供体 - 受体组合中延长了移植物存活时间。在混合淋巴细胞培养反应中测试的所有ADS批次均能阻断该反应，但未发现其体内活性与之相关。移植前用供体淋巴细胞对受体进行超免疫会导致二次排斥反应，而仅注射一次供体血液时，只有14%的情况会出现抗体产生和加速排斥反应。短期使用马抗犬淋巴细胞血清（HADLS）可延长肾移植存活时间。在此方案中添加静脉注射供体骨髓细胞并未导致移植物存活时间进一步增加。
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