Polonsky K S
Department of Medicine, The University of Chicago Pritzker School of Medicine, IL 60637, USA.
Int J Obes Relat Metab Disord. 2000 Jun;24 Suppl 2:S29-31. doi: 10.1038/sj.ijo.0801273.
Insulin resistance and compensatory hyperinsulinemia are commonly present in obesity. The biochemical mechanisms responsible for the maintenance of basal hypersecretion of insulin are reviewed in this article. Under basal, fasting and fed conditions the hyperinsulinemia of obesity largely depends on increased insulin secretion, without any alteration of the temporal secretion. This suggests that the functioning beta cell mass is enhanced, but normal regulatory mechanisms are maintained. A number of alterations in beta-cell function are present in conditions of impaired glucose tolerance which precede the onset of overt diabetes.
胰岛素抵抗和代偿性高胰岛素血症在肥胖症中普遍存在。本文综述了维持胰岛素基础分泌过多的生化机制。在基础、空腹和进食状态下，肥胖症患者的高胰岛素血症很大程度上取决于胰岛素分泌增加，而分泌时间无任何改变。这表明功能性β细胞量增加，但正常调节机制得以维持。在明显糖尿病发作之前的糖耐量受损情况下，β细胞功能存在一些改变。
