Klockgether-Radke A P, Haemmerle A, Kettler D, Hellige G
Department of Anaesthesiological Research, Centre of Anaesthesiology, Emergency Medicine and Intensive Care, Georg-August University of Göttingen, Germany.
Eur J Anaesthesiol. 2000 Aug;17(8):481-4. doi: 10.1046/j.1365-2346.2000.00712.x.
The aim of this study was to elucidate the influence of four neuromuscular blocking substances on coronary vascular tone using the model of isolated porcine coronary artery segments. We studied the effects of four muscle relaxants, atracurium, pancuronium, rocuronium, and vecuronium (0.1, 1, and 10 microg mL-1 each), on the contractile response to three vasoconstrictors: acetylcholine, histamine, and serotonin. None of the neuromuscular blocking agents under investigation exerted a significant influence on the vasoconstricting effects of these mediators except for pancuronium, which dose-dependently attenuated acetylcholine-mediated contractions (-10.8% attenuation for 10 microg mL-1 pancuronium, P < 0.05). There was no difference between vessels with intact endothelium and denuded preparations. It is concluded that high-dose pancuronium exerts an antimuscarinic effect in vascular smooth muscle. The other neuromuscular agents studied do not alter vascular reactivity of isolated porcine coronary arteries.
本研究旨在利用离体猪冠状动脉节段模型阐明四种神经肌肉阻滞剂对冠状动脉血管张力的影响。我们研究了四种肌肉松弛剂阿曲库铵、泮库溴铵、罗库溴铵和维库溴铵（各为0.1、1和10μg/mL）对三种血管收缩剂乙酰胆碱、组胺和5-羟色胺收缩反应的影响。除泮库溴铵外，所研究的神经肌肉阻滞剂均未对这些介质的血管收缩作用产生显著影响，泮库溴铵可剂量依赖性减弱乙酰胆碱介导的收缩（10μg/mL泮库溴铵时减弱10.8%，P<0.05）。有完整内皮的血管与去内皮制剂之间无差异。得出的结论是，高剂量泮库溴铵在血管平滑肌中发挥抗毒蕈碱作用。所研究的其他神经肌肉药物不会改变离体猪冠状动脉的血管反应性。
