Salis M B, Emanueli C, Milia A F, Guerrini R, Madeddu P
National Laboratory of the National Institute of Biostructures and Biosystems, Osilo, Italy.
Peptides. 2000 Jul;21(7):985-93. doi: 10.1016/s0196-9781(00)00238-2.
Nociceptin, a novel opioid peptide, and its ORL(1) receptor share structural similarities with other opioid ligands and receptors. Although NC exerts evident cardiovascular effects at a central and peripheral level, its role in homeostatic mechanisms and disease states are just beginning to be understood, as only recently selective receptor antagonists became available. In this review, some of the new observations regarding the cardiovascular actions of NC, related peptides and newly synthesized receptor antagonists are discussed.
孤啡肽是一种新型阿片肽，其孤啡肽（1）受体与其他阿片配体及受体在结构上有相似之处。尽管孤啡肽在中枢和外周水平均产生明显的心血管效应，但由于直到最近才有选择性受体拮抗剂，其在稳态机制和疾病状态中的作用才刚刚开始被了解。在这篇综述中，将讨论一些关于孤啡肽、相关肽类及新合成的受体拮抗剂心血管作用的新观察结果。
