Polidori C, de Caro G, Massi M
Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, 62032, Camerino, Italy.
Peptides. 2000 Jul;21(7):1051-62. doi: 10.1016/s0196-9781(00)00243-6.
Nociceptin/orphanin FQ (NC), the endogenous ligand of the opioid receptor-like1 (ORL1) receptor, has been reported to stimulate feeding in rats. The present article reviews the studies so far published on the effect of NC on food intake and reports new findings concerning the sensitivity of brain regions to the hyperphagic effect of NC in rats. The results obtained indicate that the hypothalamic arcuate nucleus is the most sensitive site among the brain regions so far investigated. On the basis of these findings and of the neurochemical and electrophysiological effects of NC, possible mechanisms of action and possible interactions with other neurotransmitter systems affecting feeding are discussed.
痛敏肽/孤啡肽FQ（NC）是阿片样物质受体样1（ORL1）受体的内源性配体，据报道可刺激大鼠进食。本文综述了迄今为止已发表的关于NC对食物摄入影响的研究，并报告了有关大鼠脑区对NC促食作用敏感性的新发现。所得结果表明，下丘脑弓状核是迄今为止所研究脑区中最敏感的部位。基于这些发现以及NC的神经化学和电生理作用，讨论了可能的作用机制以及与影响进食的其他神经递质系统的可能相互作用。
