Galbraith G C, Threadgill M R, Hemsley J, Salour K, Songdej N, Ton J, Cheung L
Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA,
Neurosci Lett. 2000 Oct 6;292(2):123-7. doi: 10.1016/s0304-3940(00)01436-1.
The human brainstem frequency-following response (FFR) registers phase-locked neural activity to periodic auditory stimuli. FFR waveforms were extracted from the electroencephalogram by averaging responses to repeated auditory stimulation. Two channels of data were simultaneously recorded from horizontally (electrodes placed in ear canals) and vertically (vertex scalp referenced to midline) oriented electrode configurations. Eight participants each received a total of 2000 tone repetitions for each of ten stimulus frequencies ranging from 133 to 950 Hz. FFRs were quantified by fast-Fourier spectral analysis. The largest spectral intensities at the stimulus frequency were recorded in the horizontal FFR, which also followed higher frequencies and showed better signal-to-noise ratios then did the vertical FFR. The horizontal FFR pattern suggests an acoustic nerve origin, while the vertical FFR pattern suggests a central brainstem origin.
人类脑干频率跟随反应（FFR）记录了对周期性听觉刺激的锁相神经活动。通过对重复听觉刺激的反应进行平均，从脑电图中提取FFR波形。同时从水平（电极置于耳道）和垂直（头顶头皮参考中线）定向的电极配置中记录两个通道的数据。八名参与者针对从133至950赫兹的十个刺激频率中的每一个，各自总共接受了2000次音调重复。通过快速傅里叶频谱分析对FFR进行量化。在刺激频率处最大的频谱强度记录于水平FFR中，其跟随更高频率并且相比于垂直FFR显示出更好的信噪比。水平FFR模式提示听神经起源，而垂直FFR模式提示脑干中枢起源。
