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Pathophysiology of opioid tolerance and clinical approach to the opioid-tolerant patient.

作者信息

de Leon-Casasola O, Yarussi A

机构信息

Department of Anesthesiology, Pain, and Critical Care Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.

出版信息

Curr Rev Pain. 2000;4(3):203-5. doi: 10.1007/s11916-000-0080-9.

DOI:10.1007/s11916-000-0080-9
PMID:10998734
Abstract

The physiologic basis for opioid tolerance has been elucidated, resulting in a better understanding of this problem. As a result of this ongoing effort, patients exhibiting opioid tolerance can now expect better pain management both in the postoperative period and during the course of their treatment. This article outlines the pathophysiology of opioid tolerance and a practical clinical approach to this problem.

摘要

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本文引用的文献

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The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids.N-甲基-D-天冬氨酸（NMDA）受体拮抗剂LY274614和MK-801，以及一氧化氮合酶抑制剂N-硝基-L-精氨酸，可减轻对μ阿片类吗啡的镇痛耐受性，但对κ阿片类则无此作用。
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