Spanaki M V, Kopylev L, Liow K, DeCarli C, Fazilat S, Gaillard W D, Theodore W H
Clinical Epilepsy Section, Epilepsy Research Branch, National Institutes of Health/National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892-1408, USA.
Epilepsia. 2000 Sep;41(9):1227-9. doi: 10.1111/j.1528-1157.2000.tb00330.x.
To examine the relationship between frequency of complex partial (CPS) and secondarily generalized tonic-clonic seizures (sGTCS) on hippocampal volume (HV) and temporal lobe metabolism.
We performed volumetric magnetic resonance imaging (MRI) and positron emission tomography with 18fluorodeoxyglucose (18FDG-PET) in 32 patients with epilepsy. Temporal lobe foci were localized by ictal video-EEG.
We did not find any association between CPS frequency or lifetime number of sGTCS and HV or metabolism ipsilateral to electroencephalographic focus.
The progress of metabolic or pathologic abnormalities of temporal lobe epilepsy may not be altered by adequate seizure control. The presence of an epileptic focus might be associated with progressive neuronal injury even in clinically well-controlled patients.
研究复杂部分性发作（CPS）频率与继发性全身性强直阵挛发作（sGTCS）对海马体积（HV）和颞叶代谢的关系。
对32例癫痫患者进行容积磁共振成像（MRI）和18氟脱氧葡萄糖正电子发射断层扫描（18FDG-PET）。通过发作期视频脑电图定位颞叶病灶。
我们未发现CPS频率或sGTCS的终生发作次数与脑电图病灶同侧的HV或代谢之间存在任何关联。
充分控制癫痫发作可能不会改变颞叶癫痫代谢或病理异常的进展。即使在临床控制良好的患者中，癫痫病灶的存在也可能与进行性神经元损伤有关。
