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bis-Quinolinium cyclophanes: 8,14-diaza-1,7(1, 4)-diquinolinacyclotetradecaphane (UCL 1848), a highly potent and selective, nonpeptidic blocker of the apamin-sensitive Ca(2+)-activated K(+) channel.

作者信息

Chen J Q, Galanakis D, Ganellin C R, Dunn P M, Jenkinson D H

机构信息

Departments of Chemistry and Pharmacology, University College London, Gower Street, London WC1E 6BT, U.K.

出版信息

J Med Chem. 2000 Sep 21;43(19):3478-81. doi: 10.1021/jm000904v.

DOI:10.1021/jm000904v
PMID:11000001
Abstract
摘要

相似文献

[1]
bis-Quinolinium cyclophanes: 8,14-diaza-1,7(1, 4)-diquinolinacyclotetradecaphane (UCL 1848), a highly potent and selective, nonpeptidic blocker of the apamin-sensitive Ca(2+)-activated K(+) channel.

J Med Chem. 2000-9-21

[2]
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[4]
Bis-quinolinium cyclophanes: highly potent and selective non-peptidic blockers of the apamin-sensitive Ca2+-activated K+ channel.

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[5]
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[6]
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[7]
Further studies on bis-charged tetraazacyclophanes as potent inhibitors of small conductance Ca(2+)-activated K+ channels.

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[8]
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引用本文的文献

[1]
Bis-Quinolinium Cyclophane Blockers of SK Potassium Channels Are Antagonists of M3 Muscarinic Acetylcholine Receptors.

Front Pharmacol. 2020-9-16

[2]
Pharmacology of Small- and Intermediate-Conductance Calcium-Activated Potassium Channels.

Annu Rev Pharmacol Toxicol. 2019-7-23

[3]
The relationship between functional inhibition and binding for K(Ca)2 channel blockers.

PLoS One. 2013-9-10

[4]
Calcium-activated potassium channels BK and IK1 are functionally expressed in human gliomas but do not regulate cell proliferation.

PLoS One. 2010-8-20

[5]
K+ channel modulators for the treatment of neurological disorders and autoimmune diseases.

Chem Rev. 2008-5

[6]
Competition between calcium-activated K+ channels determines cholinergic action on firing properties of basolateral amygdala projection neurons.

J Neurosci. 2008-3-19

[7]
A functional role for small-conductance calcium-activated potassium channels in sensory pathways including nociceptive processes.

J Neurosci. 2005-4-6

[8]
Small conductance Ca2+-activated K+ channels formed by the expression of rat SK1 and SK2 genes in HEK 293 cells.

J Physiol. 2003-11-15

[9]
Serotonin drives a novel GABAergic synaptic current recorded in rat cerebellar purkinje cells: a Lugaro cell to Purkinje cell synapse.

J Neurosci. 2003-6-1

[10]
Physiological role of calcium-activated potassium currents in the rat lateral amygdala.

J Neurosci. 2002-3-1

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