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本文引用的文献

1
Staphylococcal coagulase; mode of action and antigenicity.葡萄球菌凝固酶；作用方式与抗原性。
J Gen Microbiol. 1952 Feb;6(1-2):95-107. doi: 10.1099/00221287-6-1-2-95.
2
Identification and characterization of SarH1, a new global regulator of virulence gene expression in Staphylococcus aureus.金黄色葡萄球菌毒力基因表达新的全局调控因子SarH1的鉴定与特性分析
Mol Microbiol. 2000 Jul;37(2):398-409. doi: 10.1046/j.1365-2958.2000.02003.x.
3
SarA, a global regulator of virulence determinants in Staphylococcus aureus, binds to a conserved motif essential for sar-dependent gene regulation.SarA是金黄色葡萄球菌中毒力决定因素的全局调节因子，它与对sar依赖性基因调控至关重要的保守基序结合。
J Biol Chem. 1999 Dec 24;274(52):37169-76. doi: 10.1074/jbc.274.52.37169.
4
Interactive regulatory pathways control virulence determinant production and stability in response to environmental conditions in Staphylococcus aureus.交互式调控途径控制金黄色葡萄球菌中致病决定因素的产生和稳定性，以响应环境条件。
Mol Gen Genet. 1999 Sep;262(2):323-31. doi: 10.1007/s004380051090.
5
The Staphylococcal accessory regulator (sar) represses transcription of the Staphylococcus aureus collagen adhesin gene (cna) in an agr-independent manner.葡萄球菌辅助调节因子（sar）以不依赖葡萄球菌A蛋白（agr）的方式抑制金黄色葡萄球菌胶原黏附素基因（cna）的转录。
Mol Microbiol. 1999 Jul;33(2):317-26. doi: 10.1046/j.1365-2958.1999.01475.x.
6
Characterization of the SarA virulence gene regulator of Staphylococcus aureus.金黄色葡萄球菌SarA毒力基因调节因子的特性分析
Mol Microbiol. 1999 Jul;33(2):307-16. doi: 10.1046/j.1365-2958.1999.01474.x.
7
ZntR is an autoregulatory protein and negatively regulates the chromosomal zinc resistance operon znt of Staphylococcus aureus.ZntR是一种自我调节蛋白，对金黄色葡萄球菌的染色体锌抗性操纵子znt起负调节作用。
Mol Microbiol. 1999 Jul;33(1):200-7. doi: 10.1046/j.1365-2958.1999.01466.x.
8
The Staphylococcus aureus rsbW (orf159) gene encodes an anti-sigma factor of SigB.金黄色葡萄球菌rsbW（orf159）基因编码SigB的一种抗σ因子。
J Bacteriol. 1999 May;181(9):2846-51. doi: 10.1128/JB.181.9.2846-2851.1999.
9
SarA level is a determinant of agr activation in Staphylococcus aureus.SarA水平是金黄色葡萄球菌中agr激活的一个决定因素。
Mol Microbiol. 1998 Dec;30(5):991-1001. doi: 10.1046/j.1365-2958.1998.01126.x.
10
Role of SarA in virulence determinant production and environmental signal transduction in Staphylococcus aureus.SarA在金黄色葡萄球菌毒力决定因素产生及环境信号转导中的作用
J Bacteriol. 1998 Dec;180(23):6232-41. doi: 10.1128/JB.180.23.6232-6241.1998.

在纯化的体外金黄色葡萄球菌转录系统中，SarA抑制agr操纵子的表达。

SarA represses agr operon expression in a purified in vitro Staphylococcus aureus transcription system.

作者信息

Chakrabarti S K, Misra T K

机构信息

Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois 60612-7344, USA.

出版信息

J Bacteriol. 2000 Oct;182(20):5893-7. doi: 10.1128/JB.182.20.5893-5897.2000.

DOI:10.1128/JB.182.20.5893-5897.2000
PMID:11004191
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC94714/
Abstract

Mutation and genetic complementation studies suggested that two chromosomal loci, agr and sar, are involved in the upregulation of several exotoxin genes and the downregulation of a number of surface protein genes in a growth phase-dependent manner in Staphylococcus aureus. We purified recombinant T7-tagged SarA from Escherichia coli and determined its effect on transcription from several S. aureus promoters by using purified RNA polymerase reconstituted with either sigma(A) or sigma(B) from S. aureus. Of the seven sigma(A)-dependent promoters that we tested, SarA repressed transcription from agrP2, agrP3, cna, sarP1, and sea promoters and did not affect sec and znt promoters. Furthermore, SarA had no effect on transcription from the sigma(B)-dependent sarP3 promoter. In vitro experimental data presented in this report suggest that SarA expression is autoregulated.

摘要

突变和基因互补研究表明，在金黄色葡萄球菌中，两个染色体位点agr和sar以生长阶段依赖性方式参与多个外毒素基因的上调和许多表面蛋白基因的下调。我们从大肠杆菌中纯化了重组T7标签的SarA，并通过使用用来自金黄色葡萄球菌的sigma(A)或sigma(B)重组的纯化RNA聚合酶，确定了其对几个金黄色葡萄球菌启动子转录的影响。在我们测试的七个依赖sigma(A)的启动子中，SarA抑制了agrP2、agrP3、cna、sarP1和sea启动子的转录，而不影响sec和znt启动子。此外，SarA对依赖sigma(B)的sarP3启动子的转录没有影响。本报告中提供的体外实验数据表明，SarA的表达是自动调节的。