Kalasinsky K S, Bosy T Z, Schmunk G A, Ang L, Adams V, Gore S B, Smialek J, Furukawa Y, Guttman M, Kish S J
Division of Forensic Toxicology, Office of the Armed Forces Medical Examiner, Armed Forces Institute of Pathology, Washington, DC, USA.
J Forensic Sci. 2000 Sep;45(5):1041-8.
We measured concentrations of cocaine and its major metabolites (benzoylecgonine, ecgonine methylester, norcocaine, and cocaethylene) in 15 autopsied brain regions of 14 human chronic cocaine users. Only slight differences were observed in concentrations of cocaine and its metabolites amongst the examined brain areas. Although it is likely that some postmortem redistribution of the drug must have occurred, our data are consistent with the possibility that behaviorally relevant doses of cocaine are widely distributed throughout the brain of humans who use the drug on a chronic basis. Consideration should therefore be given to the possible pharmacological and toxicological actions of cocaine in both striatal and extra-striatal brain areas in human users of the drug.
我们测定了14名慢性可卡因使用者15个尸检脑区中可卡因及其主要代谢物（苯甲酰芽子碱、芽子碱甲酯、去甲可卡因和可卡因乙烯酯）的浓度。在所检查的脑区中，可卡因及其代谢物的浓度仅观察到轻微差异。尽管药物在死后很可能发生了一些重新分布，但我们的数据与以下可能性一致：即与行为相关剂量的可卡因广泛分布于长期使用该药物的人类大脑中。因此，应考虑可卡因对该药物人类使用者纹状体和纹状体以外脑区可能产生的药理和毒理作用。
