小鼠肺炎克雷伯菌和金黄色葡萄球菌感染：尿毒症和氨生成的差异。
Klebsiella pneumoniae and Staphylococcus aureus infection in mice: difference in uremia and ammoniagenesis.
作者信息
Walker R I, Chesbro W
出版信息
Infect Immun. 1975 Sep;12(3):571-5. doi: 10.1128/iai.12.3.571-575.1975.
Abstract
Lethal infections by Staphylococcus aureus and Klebsiella pneumoniae were compared for kidney-related effects in mice. K. pneumoniae caused uremia and an increase in blood ammonia that could reach 2.5 times normal. These events did not occur in mice inoculated with S. aureus. Use of germfree animals indicated that most of the increase in ammonia arose from the gut, presumably due to greater availability of urea and ureolysis. Injected ornithine restored blood ammonia to nearly normal levels and extended survival.
摘要
比较了金黄色葡萄球菌和肺炎克雷伯菌致死性感染对小鼠肾脏相关的影响。肺炎克雷伯菌导致尿毒症和血氨升高，血氨可达到正常水平的2.5倍。在接种金黄色葡萄球菌的小鼠中未出现这些情况。使用无菌动物表明，氨的增加大部分源于肠道，可能是由于尿素可用性增加和尿素分解。注射鸟氨酸可使血氨恢复到接近正常水平并延长生存期。
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