小鼠肺炎克雷伯菌和金黄色葡萄球菌感染：尿毒症和氨生成的差异。
Klebsiella pneumoniae and Staphylococcus aureus infection in mice: difference in uremia and ammoniagenesis.
作者信息
Walker R I, Chesbro W
出版信息
Infect Immun. 1975 Sep;12(3):571-5. doi: 10.1128/iai.12.3.571-575.1975.
Abstract
Lethal infections by Staphylococcus aureus and Klebsiella pneumoniae were compared for kidney-related effects in mice. K. pneumoniae caused uremia and an increase in blood ammonia that could reach 2.5 times normal. These events did not occur in mice inoculated with S. aureus. Use of germfree animals indicated that most of the increase in ammonia arose from the gut, presumably due to greater availability of urea and ureolysis. Injected ornithine restored blood ammonia to nearly normal levels and extended survival.
摘要
比较了金黄色葡萄球菌和肺炎克雷伯菌致死性感染对小鼠肾脏相关的影响。肺炎克雷伯菌导致尿毒症和血氨升高，血氨可达到正常水平的2.5倍。在接种金黄色葡萄球菌的小鼠中未出现这些情况。使用无菌动物表明，氨的增加大部分源于肠道，可能是由于尿素可用性增加和尿素分解。注射鸟氨酸可使血氨恢复到接近正常水平并延长生存期。
相似文献
1
Klebsiella pneumoniae and Staphylococcus aureus infection in mice: difference in uremia and ammoniagenesis.小鼠肺炎克雷伯菌和金黄色葡萄球菌感染：尿毒症和氨生成的差异。
Infect Immun. 1975 Sep;12(3):571-5. doi: 10.1128/iai.12.3.571-575.1975.
2
Detection of experimental infections with 99mTc-labeled monoclonal antibodies against TNF-alpha and interleukin-8.用抗TNF-α和白细胞介素-8的99mTc标记单克隆抗体检测实验性感染
Nucl Med Biol. 1997 Oct;24(7):649-55. doi: 10.1016/s0969-8051(97)00118-2.
3
Infection detection in mice using 99mTc-labeled HYNIC and N2S2 chelate conjugated to the antimicrobial peptide UBI 29-41.使用与抗菌肽UBI 29 - 41偶联的99mTc标记的HYNIC和N2S2螯合物在小鼠中进行感染检测。
Nucl Med Biol. 2004 May;31(4):503-9. doi: 10.1016/j.nucmedbio.2003.11.009.
4
5
[Antiseptic effect of compound lysostaphin disinfectant and its preventive effect on infection of artificial dermis after graft on full-thickness skin defect wound in rats].[复方溶葡萄球菌酶消毒剂的抗菌效果及其对大鼠全层皮肤缺损创面植皮后人工真皮感染的预防作用]
Zhonghua Shao Shang Za Zhi. 2018 Apr 20;34(4):225-232. doi: 10.3760/cma.j.issn.1009-2587.2018.04.007.
6
In Vivo Pharmacodynamic Target Assessment of Delafloxacin against Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumoniae in a Murine Lung Infection Model.在小鼠肺部感染模型中对达氟沙星针对金黄色葡萄球菌、肺炎链球菌和肺炎克雷伯菌的体内药效学靶点评估
Antimicrob Agents Chemother. 2016 Jul 22;60(8):4764-9. doi: 10.1128/AAC.00647-16. Print 2016 Aug.
7
Effects of hypoxic stress on survival times of mice infected with either Staphylococcus aureus or Klebsiella pneumoniae.缺氧应激对感染金黄色葡萄球菌或肺炎克雷伯菌的小鼠存活时间的影响。
Southeast Asian J Trop Med Public Health. 1974 Jun;5(2):190-6.
8
Imaging of bacterial infections with 99mTc-labeled human neutrophil peptide-1.用99mTc标记的人中性粒细胞肽-1对细菌感染进行成像。
J Nucl Med. 1999 Dec;40(12):2073-80.
9
Antibacterial Properties of Tebipenem Pivoxil Tablet, a New Oral Carbapenem Preparation against a Variety of Pathogenic Bacteria in Vitro and in Vivo.替比培南匹伐酯片（一种新型口服碳青霉烯制剂）对多种病原菌的体内外抗菌特性
Molecules. 2016 Jan 6;21(1):62. doi: 10.3390/molecules21010062.
10
[Elimination of Klebsiella pneumoniae and humoral immunity in immunization with the IS-4 immunostimulating mixture].[使用IS-4免疫刺激混合物免疫接种时肺炎克雷伯菌的清除及体液免疫]
Zh Mikrobiol Epidemiol Immunobiol. 1986 Mar(3):71-5.
本文引用的文献
1
EFFECTS OF ENDOTOXIN ON RENAL FUNCTION AND HEMODYNAMICS.内毒素对肾功能和血流动力学的影响。
Am J Physiol. 1963 Aug;205:293-7. doi: 10.1152/ajplegacy.1963.205.2.293.
2
Effect of endotoxin on kidney function and renal hemodynamics in the dog.内毒素对犬肾功能及肾血流动力学的影响。
Am J Physiol. 1961 Jul;201:144-8. doi: 10.1152/ajplegacy.1961.201.1.144.
3
Uptake of ammonia by muscle; its implications in ammoniagenic coma.肌肉对氨的摄取；其在产氨性昏迷中的意义。
N Engl J Med. 1955 Dec 29;253(26):1143-7. doi: 10.1056/NEJM195512292532602.
4
Studies on the intracerebral toxicity of ammonia.
J Clin Invest. 1967 May;46(5):838-48. doi: 10.1172/JCI105583.
5
Nitrogen metabolism in staphylococcal infected mice.葡萄球菌感染小鼠的氮代谢
Indian J Med Res. 1966 Nov;54(11):1048-52.
6
Hemolysin production in the development of staphylococcal lesions.
Science. 1965 Sep 17;149(3690):1395-6. doi: 10.1126/science.149.3690.1395.
7
Pathogenesis of hepatic encephalopathy--with special reference to the role of ammonia.
Am J Clin Nutr. 1970 May;23(5):619-32. doi: 10.1093/ajcn/23.5.619.
8
Clinical significance of intraluminal pH in intestinal ammonia transport.肠腔内pH值在肠道氨转运中的临床意义
Am J Surg. 1970 May;119(5):595-8. doi: 10.1016/0002-9610(70)90182-0.
9
The unusual role of the kidney during intoxication of monkeys by intravenous staphylococcal enterotoxin B.静脉注射葡萄球菌肠毒素B使猴子中毒时肾脏的异常作用。
J Infect Dis. 1967 Oct;117(4):273-84. doi: 10.1093/infdis/117.4.273.
10
Influence of thorotrast blockade and acute renal artery ligation on disappearance of staphylococcal enterotoxin B from blood.钍造影剂阻断和急性肾动脉结扎对葡萄球菌肠毒素B从血液中消失的影响。
J Bacteriol. 1967 Mar;93(3):779-83. doi: 10.1128/jb.93.3.779-783.1967.
Zotero 插件