米索前列醇用于宫颈成熟。
Use of misoprostol for cervical ripening.
作者信息
Katz V L, Farmer R M, Dean C A, Carpenter M E
机构信息
Sacred Heart Medical Center, Eugene, Ore, USA.
出版信息
South Med J. 2000 Sep;93(9):881-4.
BACKGROUND
Misoprostol, the prostaglandin E1 analog, is increasingly used for cervical ripening and induction of labor. We evaluated our experience with misoprostol in an open-label setting.
METHODS
Patients were selected for cervical ripening based on clinical profile. At 3 cm cervical dilation, misoprostol was discontinued and other means of labor augmentation were used. Over 13 months, 470 inductions of labor occurred, and 455 charts were available; 254 patients (56%) received misoprostol for cervical ripening, and 144 (32%) received dinoprostone (prostaglandin E2).
RESULTS
With misoprostol, mean time from beginning of contractions until delivery was 7 hours, 30 minutes; vaginal birth occurred in 85% of cases, and spontaneous labor occurred in 38%. Hyperstimulation occurred in 4 cases (1.6%) and precipitate labor in 7 (3%). All infants were discharged in excellent condition; one had a 5-minute Apgar score <7, and 33 (13%) had meconium, none with aspiration. Twenty-three patients who had had a previous cesarean section received misoprostol and delivered vaginally.
CONCLUSION
Misoprostol was found to be a safe and effective agent for cervical ripening as part of labor induction.
背景
米索前列醇，一种前列腺素E1类似物，越来越多地用于宫颈成熟和引产。我们评估了在开放标签环境下使用米索前列醇的经验。
方法
根据临床情况选择患者进行宫颈成熟。宫颈扩张至3厘米时，停用米索前列醇并采用其他引产方法。在13个月的时间里，共进行了470例引产，其中455份病历可用；254例患者（56%）接受米索前列醇进行宫颈成熟，144例（32%）接受地诺前列酮（前列腺素E2）。
结果
使用米索前列醇时，从开始宫缩到分娩的平均时间为7小时30分钟；85%的病例实现阴道分娩，38%为自然分娩。4例（1.6%）出现子宫收缩过强，7例（3%）出现急产。所有婴儿均状况良好出院；1例5分钟阿氏评分<7，33例（13%）有胎粪，均无吸入。23例曾行剖宫产的患者接受米索前列醇并经阴道分娩。
结论
米索前列醇被发现是一种安全有效的宫颈成熟药物，可作为引产的一部分。
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