Kirchhoff H W
Int J Clin Pharmacol Biopharm. 1975 Jul;12(1-2):152-7.
In a double-blind study the influence of Demetrin on cardiovascular activity was investigated. Basic values before treatment were compared with values after 1 and 2 weeks' administration. The cardiovascular parameters "pulse rate" and "blood pressure" were studied in the orthostatic tolerance test (pivoting table) and in the bicycle ergometer test. Results were evaluated with variance analysis. Demetrin at dosage levels of 3 x 10 mg/day and 3 x 20 mg/day did not influence cardiovascular function. Occasionally mild sedation was observed.
在一项双盲研究中，研究了Demetrin对心血管活动的影响。将治疗前的基础值与给药1周和2周后的数值进行比较。在直立耐力试验（旋转台）和自行车测力计试验中研究了心血管参数“脉搏率”和“血压”。结果采用方差分析进行评估。剂量水平为3×10毫克/天和3×20毫克/天的Demetrin对心血管功能没有影响。偶尔观察到轻度镇静作用。
