Schmitz-Spanke S, Schipke J D
Zentrum für Operative Medizin I, Forschungsgruppe Experimentelle Chirurgie, Heinrich-Heine-Universität Düsseldorf, Germany.
Basic Res Cardiol. 2000 Aug;95(4):290-8. doi: 10.1007/s003950070048.
The endothelins comprise a family of three isopeptides ET-1, ET-2 and ET-3, whereby ET-1 appears to be the most relevant in humans. They act in a paracrine manner on ETA and ETB receptors. ET-1 plays an important role in the cardiovascular system. In addition, it modulates vasomotion and growth processes, and it participates in thrombogenesis and neutrophil adhesion. This review summarizes some of the current literature pertaining to the physiological and pathophysiological significance of ET-1, focusing the assets and drawbacks of elevated ET-1 levels. In this regard, modulation of the endothelin system by either receptor blockade or by inhibition of endothelin converting enzyme is expected to provide novel therapeutic drug strategies.
内皮素由ET-1、ET-2和ET-3三种异肽组成一个家族，其中ET-1在人类中似乎最为重要。它们以旁分泌方式作用于ETA和ETB受体。ET-1在心血管系统中起重要作用。此外，它调节血管运动和生长过程，并参与血栓形成和中性粒细胞黏附。本综述总结了一些有关ET-1生理和病理生理意义的当前文献，重点关注ET-1水平升高的利弊。在这方面，通过受体阻断或抑制内皮素转化酶来调节内皮素系统有望提供新的治疗药物策略。
