Cerne K, Drevensek G, Budihna M V
Department of Pharmacology and Experimental Toxicology, Faculty of Medicine, Ljubljana, Slovenia.
Pflugers Arch. 2000;440(5 Suppl):R139-40.
The venom of the honeybee Apis mellifera induces cardiovascular dysfunction. As its effects on coronary arteries have not yet been described, we studied the effects of the whole honeybee venom (non-volatile part) in the isolated porcine left anterior descending coronary artery (LAD) and the influence of L-type Ca2+ channel blocker, lacidipine, upon the venom effects in LAD. The venom produced concentration dependent contractions (7-70 microg/ml) of the porcine LAD; maximal effect of the venom was approximately the same as the effect of 30 mM KCl. Lacidipine concentration dependently (0.1-10 microM) and significantly (P < or = 0.05) decreased the venom-induced vasoconstriction. The results indicate the involvement of L-type Ca2+ channels in coronary contraction, induced by bee venom.
蜜蜂（意大利蜜蜂）的毒液会引发心血管功能障碍。由于其对冠状动脉的影响尚未见报道，我们研究了全蜂毒（非挥发性部分）对离体猪左冠状动脉前降支（LAD）的作用，以及L型钙通道阻滞剂拉西地平对LAD中蜂毒作用的影响。蜂毒对猪LAD产生浓度依赖性收缩（7 - 70微克/毫升）；蜂毒的最大效应与30毫摩尔氯化钾的效应大致相同。拉西地平浓度依赖性地（0.1 - 10微摩尔）且显著地（P≤0.05）降低了蜂毒诱导的血管收缩。结果表明L型钙通道参与了蜂毒诱导的冠状动脉收缩。
