Ong Y K, Tan H K
Department of Otolaryngology, National University Hospital, 5 Lower Kent Ridge Road, Singapore, Singapore.
Int J Pediatr Otorhinolaryngol. 2000 Sep 29;55(2):149-54. doi: 10.1016/s0165-5876(00)00385-2.
Nasopharyngeal carcinoma (NPC) is rare in children. We report two cases from KK Women and Children's Hospital in Singapore, who presented with advanced locoregional disease. The various aspects of NPC in children are discussed. It is more common in males and black adolescents. The etiology is probably different from that in adult. Undifferentiated NPC or lymphoepithelioma is the commonest variety. Confusing symptoms like cervical lymphadenopathy and unilateral otitis media with effusion (OME) are among the commonest presentations. When children present with both conditions simultaneously, it is imperative to manage them like adult patients and perform nasendoscopy to rule out NPC. The disease stage at presentation is often more advanced compared with adults. These tumors are, however, associated with a higher cure rate as they are most radiosensitive. Radiotherapy with neo-adjuvant chemotherapy is currently the treatment of choice. Both cases achieved satisfactory control of the disease and are presently under close follow-up.
鼻咽癌（NPC）在儿童中较为罕见。我们报告了新加坡KK妇女儿童医院的两例病例，这两名患儿均表现为局部晚期疾病。本文讨论了儿童鼻咽癌的各个方面。该病在男性和黑人青少年中更为常见。其病因可能与成人不同。未分化鼻咽癌或淋巴上皮瘤是最常见的类型。最常见的症状包括颈部淋巴结肿大和单侧渗出性中耳炎（OME）等易混淆症状。当儿童同时出现这两种情况时，必须像成人患者一样进行处理，并进行鼻内镜检查以排除鼻咽癌。与成人相比，患儿就诊时的疾病分期往往更晚。然而，这些肿瘤对放疗最为敏感，因此治愈率较高。目前，新辅助化疗联合放疗是首选治疗方法。两例病例均实现了对疾病的满意控制，并正在接受密切随访。
