Cohen A M
Lucille Markey Cancer Center, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536-0098, USA.
Surg Oncol Clin N Am. 2000 Oct;9(4):741-7; discussion 749-50.
The major goals in the treatment of patients with rectal cancer are overall cure, maximizing local control, and maintaining quality of life. Quality of life issues include avoidance of a permanent stoma and maintaining adequate bowel, sexual, and urinary function. Optimizing the surgical technique with a more selective application of adjuvant therapy will meet these goals. This article describes the likely explanations for local and distant recurrence and delineates current clinical trials of adjuvant therapy directed toward minimizing failure despite potentially curative surgical resection.
直肠癌患者治疗的主要目标是实现整体治愈、最大限度地实现局部控制并维持生活质量。生活质量问题包括避免永久性造口以及维持适当的肠道、性功能和排尿功能。通过更有选择性地应用辅助治疗来优化手术技术将实现这些目标。本文描述了局部和远处复发的可能原因，并阐述了旨在尽量减少尽管进行了潜在根治性手术切除但仍出现失败情况的辅助治疗的当前临床试验。
