Reaction of COTC with glutathione: structure of the putative glyoxalase I inhibitor.
作者信息
Huntley C F, Hamilton D S, Creighton D J, Ganem B
机构信息
Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York 14853-1301, USA.
出版信息
Org Lett. 2000 Oct 5;2(20):3143-4. doi: 10.1021/ol006341z.
PMID:11009366
Abstract
The structure of the active glyoxalase I inhibitor derived from the Streptomyces griseosporeus metabolite COTC 1 has been conclusively identified by means of total synthesis as 2c. Human glyoxalase I is competitively inhibited by 2c (K(i)() = 183 +/- 6 microM) but is not inhibited by 1 itself.
摘要
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