Klahr S, Rodriguez H J
Nephron. 1975;15(3-5):387-408. doi: 10.1159/000180522.
The factors that control sodium excretion have been the subject of considerable work in recent years. The natriuresis that follows expansion of the extracellular fluid volume is mediated to a large extent by inhibition of tubular sodium reabsorption. Of the several mechanisms proposed to explain this inhibition, considerable interest has followed the suggestion that a humoral substance is released into the blood stream in response to volume expansion. The present article reviews the evidence for and against the existence of such a humoral substance (natriuretic hormone). It also discusses its proposed chemical nature and its possible site of origin in the organism as well as its mode of action.
近年来，控制钠排泄的因素一直是大量研究的主题。细胞外液量扩张后出现的利钠作用在很大程度上是通过抑制肾小管钠重吸收来介导的。在为解释这种抑制作用而提出的几种机制中，有人提出体液物质会因容量扩张而释放到血流中，这一观点引起了广泛关注。本文回顾了支持和反对这种体液物质（利钠激素）存在的证据。文章还讨论了其推测的化学性质、在机体中可能的起源部位以及作用方式。
