Mori O, Ohaki Y, Oguro T, Shimizu H, Qun H, Arai S, Yamazaki M, Arai Y, Asano G
Department of Pathology, Nippon Medical School, Tokyo, Japan.
Hum Pathol. 2000 Sep;31(9):1175-8. doi: 10.1053/hupa.2000.17996.
A case of early cerebral malaria caused by Plasmodium falciparum was studied. P-selectin glycoprotein ligand 1 (PL1) was detected along the inner surface of the infected red blood cells (IRBCs), which ordinarily are not positive for PL1 immunohistochemically, suggesting PL1 being the product of parasite. The electron microscopic finding showed granular deposits in the corresponding lesion, consistent with PL1 deposition, in the IRBCs firmly attached to the endothelium of small cerebral vessels. Most of the IRBCs were round shaped as though they lost their capacity to change shape. The therapeutic strategy was expected against adhesion molecules such as PL1 and for maintaining or restoring the metamorphic capacity of IRBCs.
对1例由恶性疟原虫引起的早期脑型疟病例进行了研究。在感染的红细胞（IRBCs）内表面检测到P-选择素糖蛋白配体1（PL1），而IRBCs通常在PL1免疫组化中呈阴性，这表明PL1是寄生虫的产物。电子显微镜检查发现，在牢固附着于脑小血管内皮的IRBCs中，相应病变处有颗粒状沉积物，与PL1沉积一致。大多数IRBCs呈圆形，似乎失去了变形能力。预期治疗策略是针对PL1等黏附分子，并维持或恢复IRBCs的变形能力。
