Hossain M S, Salam M A, Rabbani G H, Biswas R, Mahalanabis D
ICDDR,B: Centre for Health and Population Research, Dhaka, Bangladesh.
J Health Popul Nutr. 2000 Jun;18(1):27-32.
A prospective study was conducted to determine the clinical and laboratory characteristics and the clinical course of cholera due to Vibrio cholerae O139 Bengal. The study subjects included 22 adult males with stool culture-proven V. cholerae O139. On enrollment, mean +/- SD concentrations (mmol/L) of serum sodium, potassium, chloride, and bicarbonate were 134 +/- 3, 4 +/- 1, 102 +/- 4, and 13 +/- 4 respectively, and stool sodium, potassium, chloride, and bicarbonate concentrations were 120 +/- 24, 18 +/- 6, 93 +/- 16, and 37 +/- 9 respectively. Seventeen patients (7.8%) had faecal leukocytes ranging from 11 to 50 per high-power field. All V. cholerae O139 isolates (100%) were susceptible to tetracycline, erythromycin, and ciprofloxacin, 92% to furazolidine, and only 5% to trimethoprim-sulphamethaxazole. The median (interquartile) volume of liquid stool during the first 24 hours was 9 (5-12) litre. The median (interquartile) volume of liquid stool and the amounts of intravenous and oral rehydration fluids required during the entire study period were 16 (9-24) litre, 9 (6-18) litre, and 14 (9-20) litre respectively. The median (interquartile) duration of diarrhoea was 80 (48-104) hours. The median (interquartile) duration of excretion of V. cholerae O139 in stool was 5 (3-6) days. Clinical and laboratory features, and case management of cholera due to V. cholerae O139 are very similar to conventional cholera due to V. cholerae O1.
开展了一项前瞻性研究，以确定由O139群霍乱弧菌（孟加拉型）引起的霍乱的临床和实验室特征以及临床病程。研究对象包括22名粪便培养证实感染O139群霍乱弧菌的成年男性。入组时，血清钠、钾、氯和碳酸氢盐的平均±标准差浓度（mmol/L）分别为134±3、4±1、102±4和13±4，粪便钠、钾、氯和碳酸氢盐浓度分别为120±24、18±6、93±16和37±9。17例患者（7.8%）每高倍视野粪便白细胞数为11至50个。所有O139群霍乱弧菌分离株（100%）对四环素、红霉素和环丙沙星敏感；对呋喃唑酮的敏感率为92%；对甲氧苄啶-磺胺甲恶唑的敏感率仅为5%。最初24小时内液体粪便的中位数（四分位间距）量为9（5 - 12）升。整个研究期间液体粪便的中位数（四分位间距）量以及所需静脉和口服补液量分别为16（9 - 24）升、9（6 - 18）升和14（9 - 20）升。腹泻的中位数（四分位间距）持续时间为80（48 - 104）小时。粪便中O139群霍乱弧菌排泄的中位数（四分位间距）持续时间为5（3 - 6）天。由O139群霍乱弧菌引起的霍乱的临床和实验室特征以及病例管理与由O1群霍乱弧菌引起的传统霍乱非常相似。
