Sari R, Yildirim B, Sevinc A, Buyukberber S
Department of Internal Medicine, School of Medicine, Inonu University, Turgut Ozal Medical Center, Malatya, Turkey.
J Health Popul Nutr. 2000 Jun;18(1):54-6.
Two cases of newly-diagnosed asymptomatic coeliac disease with 3 years of unexplained severe iron-deficiency anaemia are presented. Oral iron supplementation had no effect on their serum iron levels and, therefore, had no influence on their anaemia. Upper gastrointestinal endoscopy confirmed normal macroscopic findings. Duodenal biopsies revealed subtotal villous atrophy of the mucosa of the small intestine. A strict gluten-free diet led to an increase in serum iron, resolution of anaemia, and restitution of normal mucosal morphology. Thus, severe iron-deficiency anaemia associated with asymptomatic coeliac disease is responsible to gluten-free diet.
本文报告了两例新诊断的无症状乳糜泻病例，患者有3年不明原因的严重缺铁性贫血。口服铁剂补充对其血清铁水平没有影响，因此对贫血也没有作用。上消化道内镜检查证实宏观检查结果正常。十二指肠活检显示小肠黏膜绒毛出现大面积萎缩。严格的无麸质饮食使血清铁增加，贫血得到缓解，黏膜形态恢复正常。因此，与无症状乳糜泻相关的严重缺铁性贫血可通过无麸质饮食得到改善。
