Pattyn S R, Saerens E J
Zentralbl Bakteriol Orig A. 1975 May;231(4):503-7.
The total minimal inhibitory dose of rifampicin determined in the experimental mouse model, was found to be 10 mg/kg body weight, administered once a week for 6 weeks or once every 2 weeks for 12 weeks. From these and other results it is suggested that administration of RMP in human treatment can be reduced to a total amount of 7.2 either as a 600 mg dose once a week for 12 weeks or as a 900 mg dose once a week for 8 weeks. At present these regimens can only be used as an introductory treatment for multibacillary cases and are still too expensive for developing countries, but their efficacy should be evaluated in the field as sole treatments in tuberculoid cases, since they could signify a substantial economy for the management of the majority of leprosy infections.
在实验小鼠模型中确定的利福平总最小抑菌剂量为10毫克/千克体重，每周给药一次，共6周，或每2周给药一次，共12周。从这些结果和其他结果表明，在人类治疗中利福平的给药总量可减至7.2，即每周一次600毫克剂量，共12周，或每周一次900毫克剂量，共8周。目前，这些治疗方案仅可用于多菌型病例的初始治疗，对发展中国家来说仍然过于昂贵，但它们作为结核样型病例的单一治疗方法在实地的疗效应予以评估，因为它们可能意味着在大多数麻风感染管理方面的大量节省。
