Reed R G, Kris-Etherton P, Stewart P W, Pearson T A
M.I. Bassett Research Institute, Bassett Healthcare, Cooperstown, NY 13326, USA.
Metabolism. 2000 Sep;49(9):1101-5. doi: 10.1053/meta.2000.8603.
Numerous studies have reported cyclic fluctuations in lipids and lipoproteins as a function of the phase of the menstrual cycle. However, the reported patterns are quite variable and have led to an unclear picture of the influence of the menstrual cycle on the variability of lipids, and hence of the role of the menstrual cycle phase in the interpretation of serum lipids for premenopausal women. As part of the DELTA Study (Dietary Effects on Lipoproteins and Thrombogenic Activity), we evaluated the cyclic variation of circulating lipids and lipoproteins in 39 premenopausal women and compared intraindividual variances in these women, 18 postmenopausal women, and 46 men under conditions of tight dietary control. Cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, triglyceride, apolipoproteins A-1 (apo A-1) and B-100 (apo B-100), and lipoprotein (a) [Lp(a)] all demonstrated cycling in the premenopausal women. However, the observed cycling accounts for only a small fraction of the total biologic variability of lipids in premenopausal women. The magnitude of total intraindividual variability based on coefficient of variation (CV) for these lipids in premenopausal women (CV, 4% to 8.1%) was similar to that found for men (CV, 4.3% to 9.1%) and for postmenopausal women (CV, 3.7% to 6.7%). These results suggest that protocols for screening and monitoring of serum lipids in premenopausal women need not differ from those used for men or postmenopausal women.
大量研究报告称，脂质和脂蛋白会随着月经周期的阶段出现周期性波动。然而，所报告的模式差异很大，导致月经周期对脂质变异性的影响尚不明确，进而月经周期阶段在绝经前女性血清脂质解读中的作用也不清晰。作为DELTA研究（饮食对脂蛋白和血栓形成活性的影响）的一部分，我们评估了39名绝经前女性循环脂质和脂蛋白的周期性变化，并比较了这些女性、18名绝经后女性和46名男性在严格饮食控制条件下的个体内差异。胆固醇、高密度脂蛋白（HDL）胆固醇、低密度脂蛋白（LDL）胆固醇、甘油三酯、载脂蛋白A-1（apo A-1）和B-100（apo B-100）以及脂蛋白（a）[Lp（a）]在绝经前女性中均呈现周期性变化。然而，观察到的周期性变化仅占绝经前女性脂质总生物学变异性的一小部分。基于变异系数（CV），绝经前女性这些脂质的个体内总变异性幅度（CV，4%至8.1%）与男性（CV，4.3%至9.1%）和绝经后女性（CV，3.7%至6.7%）相似。这些结果表明，绝经前女性血清脂质筛查和监测方案无需与男性或绝经后女性的方案有所不同。
