Rb/E2F信号通路：不断扩展的作用与新出现的模式 - Suppr

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The Rb/E2F pathway: expanding roles and emerging paradigms.

作者信息

Harbour J W, Dean D C

机构信息

Division of Molecular Oncology, Washington University, St. Louis, Missouri 63110, USA.

出版信息

Genes Dev. 2000 Oct 1;14(19):2393-409. doi: 10.1101/gad.813200.

DOI:10.1101/gad.813200

PMID:11018009

Abstract

摘要

相似文献

The Rb/E2F pathway: expanding roles and emerging paradigms.

Genes Dev. 2000 Oct 1;14(19):2393-409. doi: 10.1101/gad.813200.

Retinoblastoma-repression of E2F-dependent transcription depends on the ability of the retinoblastoma protein to interact with E2F and is abrogated by the adenovirus E1A oncoprotein.

Nucleic Acids Res. 1992 Nov 25;20(22):5947-54. doi: 10.1093/nar/20.22.5947.

Transient accumulation of retinoblastoma/E2F-1 protein complexes correlates with the onset of neuronal differentiation in the developing quail neural retina.

Cell Growth Differ. 1998 Oct;9(10):857-67.

Toward an understanding of the functional complexity of the E2F and retinoblastoma families.

Cell Growth Differ. 1998 Aug;9(8):585-93.

The cell cycle-regulating transcription factors E2F-RB.

Br J Cancer. 1999 Jul;80 Suppl 1:38-41.

The retinoblastoma protein and cell cycle control.

Cell. 1995 May 5;81(3):323-30. doi: 10.1016/0092-8674(95)90385-2.

Activation of a retinoblastoma-protein-dependent pathway by sphingosine.

Biochem J. 1995 Sep 1;310 ( Pt 2)(Pt 2):453-9. doi: 10.1042/bj3100453.

E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites.

Proc Natl Acad Sci U S A. 1997 May 13;94(10):4948-53. doi: 10.1073/pnas.94.10.4948.

Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5436-40. doi: 10.1073/pnas.92.12.5436.

Complexes containing the retinoblastoma gene product recognize different DNA motifs related to the E2F binding site.

Oncogene. 1992 Jun;7(6):1075-81.

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The Rb/E2F pathway: expanding roles and emerging paradigms.

作者信息

Harbour J W, Dean D C

机构信息

Division of Molecular Oncology, Washington University, St. Louis, Missouri 63110, USA.

出版信息

Genes Dev. 2000 Oct 1;14(19):2393-409. doi: 10.1101/gad.813200.

DOI:10.1101/gad.813200

PMID:11018009

Abstract

摘要

相似文献

The Rb/E2F pathway: expanding roles and emerging paradigms.

Genes Dev. 2000 Oct 1;14(19):2393-409. doi: 10.1101/gad.813200.

Retinoblastoma-repression of E2F-dependent transcription depends on the ability of the retinoblastoma protein to interact with E2F and is abrogated by the adenovirus E1A oncoprotein.

Nucleic Acids Res. 1992 Nov 25;20(22):5947-54. doi: 10.1093/nar/20.22.5947.

Transient accumulation of retinoblastoma/E2F-1 protein complexes correlates with the onset of neuronal differentiation in the developing quail neural retina.

Cell Growth Differ. 1998 Oct;9(10):857-67.

Toward an understanding of the functional complexity of the E2F and retinoblastoma families.

Cell Growth Differ. 1998 Aug;9(8):585-93.

The cell cycle-regulating transcription factors E2F-RB.

Br J Cancer. 1999 Jul;80 Suppl 1:38-41.

The retinoblastoma protein and cell cycle control.

Cell. 1995 May 5;81(3):323-30. doi: 10.1016/0092-8674(95)90385-2.

Activation of a retinoblastoma-protein-dependent pathway by sphingosine.

Biochem J. 1995 Sep 1;310 ( Pt 2)(Pt 2):453-9. doi: 10.1042/bj3100453.

E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites.

Proc Natl Acad Sci U S A. 1997 May 13;94(10):4948-53. doi: 10.1073/pnas.94.10.4948.

Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5436-40. doi: 10.1073/pnas.92.12.5436.

Complexes containing the retinoblastoma gene product recognize different DNA motifs related to the E2F binding site.

Oncogene. 1992 Jun;7(6):1075-81.

引用本文的文献

Optochemical control of G1 cell cycle by regulating CDK4/6 degradation.

iScience. 2025 Aug 6;28(9):113304. doi: 10.1016/j.isci.2025.113304. eCollection 2025 Sep 19.

MEIOC prevents continued mitotic cycling and promotes meiotic entry during mouse oogenesis.

bioRxiv. 2025 Jun 15:2025.06.12.659330. doi: 10.1101/2025.06.12.659330.

CD47-mediated regulation of glucose and lipid metabolism: implications for the pathogenesis of MASLD.

Front Endocrinol (Lausanne). 2025 Jun 24;16:1535382. doi: 10.3389/fendo.2025.1535382. eCollection 2025.

Molecular Landscape of Endometrial Stromal Tumors.

JCO Precis Oncol. 2025 May;9:e2400779. doi: 10.1200/PO-24-00779. Epub 2025 May 22.

Mechanistic Roles of Transcriptional Cyclin-Dependent Kinases in Oncogenesis: Implications for Cancer Therapy.

Cancers (Basel). 2025 May 3;17(9):1554. doi: 10.3390/cancers17091554.

Mechanisms of adipocyte regulation: Insights from HADHB gene modulation.

PLoS One. 2025 Mar 27;20(3):e0319384. doi: 10.1371/journal.pone.0319384. eCollection 2025.

Insulin-like growth factor 2 as a driving force for exponential expansion and differentiation of the neonatal thymus.

Development. 2025 Apr 1;152(7). doi: 10.1242/dev.204347. Epub 2025 Apr 10.

Carbon ion irradiation conquers the radioresistance by inducing complex DNA damage and apoptosis in U251 human glioblastomas cells.

Med Oncol. 2025 Feb 4;42(3):64. doi: 10.1007/s12032-025-02616-5.

Expression of Wnt signaling proteins LEF1, β-catenin, GSK3β, DVL1, and N-myc varies across retinoblastoma subtypes and pRb phosphorylation status.

Sci Rep. 2024 Dec 30;14(1):31725. doi: 10.1038/s41598-024-82044-z.

Stress Can Induce Bovine Alpha-Herpesvirus 1 (BoHV-1) Reactivation from Latency.

Viruses. 2024 Oct 27;16(11):1675. doi: 10.3390/v16111675.