Schein P S, Chabner B A, Canellos G P, Young R D, Berard C, DeVita V T
Br J Cancer Suppl. 1975 Mar;2:465-73.
The analysis of the results of CVP and MOPP chemotherapy in 80 patients with advanced stages of non-Hodgkin's lymphoma shows that 36 achieved a complete remission. Twenty-five percent of all patients remain free of disease for periods ranging from 4 months to over 7 years, with a projected median duration of complete remissions of 3 1/2 years. Well differentiated and nodular histology were positive determinants for survival, confirming the overall clinical validity of the Rappaport classification system for the non-Hodgkin's lymphomata. However, it has been demonstrated that it is possible to achieve a complete remission using combination chemotherapy even in the most clinically aggressive histological subgroups, and that these responses can be correlated with an extended survival. An analysis of patterns of relapse from complete remission in patients with non-Hodgkin's lymphoma treated with combination chemotherapy has demonstrated differences between histological subgroups. Patients with diffuse histiocytic lymphoma who achieved a complete remission after 6 months of treatment without maintenance have remained disease-free, whereas those with nodular poorly differentiated lymphocytic and diffuse well differentiated lymphocytic lymphomata demonstrate a pattern of continuous late recurrence. The initial sites of relapse from complete remission in lymphocytic lymphoma were lymph nodes and bone marrow which were involved before treatment.
对80例晚期非霍奇金淋巴瘤患者进行CVP和MOPP化疗的结果分析显示，36例实现了完全缓解。所有患者中有25%在4个月至7年以上的时间内无疾病，预计完全缓解的中位持续时间为3.5年。高分化和结节性组织学是生存的阳性决定因素，证实了Rappaport分类系统对非霍奇金淋巴瘤的总体临床有效性。然而，已经证明，即使在临床上最具侵袭性的组织学亚组中，联合化疗也有可能实现完全缓解，并且这些反应与生存期延长相关。对接受联合化疗的非霍奇金淋巴瘤患者完全缓解后的复发模式分析表明，组织学亚组之间存在差异。弥漫性组织细胞淋巴瘤患者在6个月治疗后未进行维持治疗而实现完全缓解，一直无疾病，而结节性低分化淋巴细胞性和弥漫性高分化淋巴细胞性淋巴瘤患者则表现出持续的晚期复发模式。淋巴细胞性淋巴瘤完全缓解后的初始复发部位是治疗前受累的淋巴结和骨髓。
