Sobhani I
Service de gastro-entérologie, Hôpital Bichat-Claude-Bernard, Paris.
Rev Prat. 2000 Sep 1;50(13):1427-30.
Helicobacter pylori is a risk factor for gastric carcinoma and an established carcinogenic bacterium. The relative risk to induce a gastric cancer is estimated to be 3 to 6 compared to that of individuals without H. pylori. Gastric atrophy and intestinal metaplasia in gastric mucosa are 2 well recognized precancerous lesions. Their occurrence and evolution are multifactorial depending on age at first infection, duration of infection and host's genetic characteristics. Prevention using H. pylori eradication is recommended only in individuals with high risk of cancer. Gastric lymphoma, although less frequent, may be due to H. pylori infection. Only in low grade lymphoma H. pylori eradication and periodic surveillance are recommended.
幽门螺杆菌是胃癌的一个风险因素,是一种已确定的致癌细菌。与未感染幽门螺杆菌的个体相比,诱发胃癌的相对风险估计为3至6。胃黏膜萎缩和肠化生是两种公认的癌前病变。它们的发生和演变是多因素的,取决于初次感染的年龄、感染持续时间和宿主的遗传特征。仅建议在癌症高危个体中使用根除幽门螺杆菌的方法进行预防。胃淋巴瘤虽然不太常见,但可能是由幽门螺杆菌感染引起的。仅在低级别淋巴瘤中,建议根除幽门螺杆菌并进行定期监测。