[大鼠实验性肾毒性肾炎中血液白细胞酶活性的研究]
[Study of the enzymatic activity of the blood leukocytes in experimental nephrotoxic nephritis in rats].
作者信息
Chenchikova E P, Katosova L K, Potapova I N, Balandina E K
出版信息
Biull Eksp Biol Med. 1975 Aug;80(8):53-7.
The enzymatic activity of blood leukocytes was studied in rats with Masugi nephritis by means of the quantitative cytochemical method. Nephrotoxin injection during first hours and days did not produce specific changes in the enzymatic activity. Maximum changes were observed on the 8-th day when the elevation of the activity of dehydrogenase lymphocytes and neutrophils acid phosphatase was observed at the same time with most pronounced histological changes in the kidneys, the decrease of the complement titer and the presence of nephrotoxin and autoglobulin in the renal glomeruli. Later the histological changes became less pronounced, and the enzymatic activity decreased. In rats with proteinuria the activity of the neutrophil leukocytes acid phosphatase was higher than in animals without proteinuria.
采用定量细胞化学方法研究了Masugi肾炎大鼠血液白细胞的酶活性。在最初的数小时和数天内注射肾毒素并未引起酶活性的特异性变化。在第8天观察到最大变化，此时脱氢酶淋巴细胞和中性粒细胞酸性磷酸酶活性升高，同时肾脏出现最明显的组织学变化、补体滴度降低以及肾小球中存在肾毒素和自身球蛋白。随后组织学变化变得不那么明显，酶活性也降低。有蛋白尿的大鼠中性粒细胞酸性磷酸酶活性高于无蛋白尿的动物。
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