Goebel M U, Mills P J
Department of Psychiatry, University of California, San Diego, La Jolla, USA.
Psychosom Med. 2000 Sep-Oct;62(5):664-70. doi: 10.1097/00006842-200009000-00010.
This study examined the effects of acute psychological stress and exhaustive exercise on the expression and density of adhesion molecules (L-selectin, lymphocyte function antigen-1 [LFA-1], and intracellular adhesion molecule-1 [ICAM-1]) on monocytes, granulocytes, and lymphocytes.
Forty-five healthy volunteers performed a 15-minute public speaking task and a 15- to 18-minute bicycle ergometer challenge.
In general, both the exercise and speaking tasks led to increases in the number of circulating leukocytes and lymphocyte subsets. The density of L-selectin (CD62L) on mixed lymphocytes and T lymphocytes was decreased in response to exercise (p values < .001). Both stressors led to an increased density of LFA-1 (CD11a) on mixed lymphocytes (p values < .01), whereas CD11a density on monocytes and granulocytes remained unchanged. ICAM-1 (CD54) density was unaffected, but the number of lymphocytes, monocytes, and granulocytes expressing CD54 increased in the circulation on both stressors.
The data indicate that both psychological stress and exercise have significant effects on cellular expression of adhesion molecules on circulating leukocytes. Given the crucial role that adhesion molecules on circulating cells play in inflammation and disease, these findings may have clinical relevance in sympathetic nervous system-induced immune activation.
本研究探讨急性心理应激和力竭运动对单核细胞、粒细胞和淋巴细胞上黏附分子（L-选择素、淋巴细胞功能相关抗原-1 [LFA-1] 和细胞间黏附分子-1 [ICAM-1]）表达及密度的影响。
45名健康志愿者进行了15分钟的公众演讲任务和15至18分钟的自行车测力计挑战。
总体而言，运动和演讲任务均导致循环白细胞和淋巴细胞亚群数量增加。运动后，混合淋巴细胞和T淋巴细胞上L-选择素（CD62L）的密度降低（p值<0.001）。两种应激源均导致混合淋巴细胞上LFA-1（CD11a）的密度增加（p值<0.01），而单核细胞和粒细胞上的CD11a密度保持不变。ICAM-1（CD54）密度未受影响，但两种应激源作用下循环中表达CD54的淋巴细胞、单核细胞和粒细胞数量均增加。
数据表明，心理应激和运动均对循环白细胞上黏附分子的细胞表达有显著影响。鉴于循环细胞上的黏附分子在炎症和疾病中起关键作用，这些发现可能在交感神经系统诱导的免疫激活方面具有临床意义。
