Krol B J, Righi P D, Paydarfar J A, Cheng E T, Smith R M, Lai D C, Bhargava V, Piccirillo J F, Hayes J T, Lue A J, Scher R L, Weisberger E C, Wilson K M, Tran L E, Rizk N, Pellitteri P K, Terris D J
Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis 46202-5230, USA.
Otolaryngol Head Neck Surg. 2000 Oct;123(4):368-76. doi: 10.1067/mhn.2000.107680.
The goal was to identify factors associated with the outcome of salvage therapy for patients with isolated cervical recurrences of squamous cell carcinoma in the previously treated neck (ICR-PTN).
A tumor registry search for ICR-PTN patients was performed at 7 participating institutions, and the charts were reviewed. Kaplan-Meier plots for survival and time until re-recurrence were used to evaluate the significance of associated variables.
Median survival and time until re-recurrence were both 11 months. Survival was better in patients with the following characteristics: nonsurgical initial neck treatment, negative initial disease resection margins, no history of prior recurrence, ipsilateral location of the ICR-PTN relative to the primary, and use of surgical salvage.
By pooling the experience of 7 US tertiary care medical centers, we have identified 5 factors that are associated with outcome of salvage therapy for ICR-PTN.
Consideration of these factors, as well as the reviewed literature, should facilitate patient selection for salvage protocols.
目标是确定与先前治疗过的颈部孤立性宫颈鳞状细胞癌复发（ICR-PTN）患者挽救治疗结果相关的因素。
在7家参与机构对ICR-PTN患者进行肿瘤登记搜索，并对病历进行回顾。使用Kaplan-Meier生存曲线和直至再次复发的时间来评估相关变量的显著性。
中位生存期和直至再次复发的时间均为11个月。具有以下特征的患者生存情况较好：初次颈部非手术治疗、初次疾病切除边缘阴性、无既往复发史、ICR-PTN相对于原发灶位于同侧以及采用手术挽救治疗。
通过汇总7家美国三级医疗中心的经验，我们确定了5个与ICR-PTN患者挽救治疗结果相关的因素。
考虑这些因素以及已回顾的文献，应有助于为挽救方案选择患者。
