Management of women with polycystic ovary syndrome who experienced premature luteinization during clomiphene citrate treatment.

OBJECTIVE

To determine the preferred treatment modality in patients with PCOS who experienced premature luteinization during CC treatment.

DESIGN

Prospective randomized study.

SETTING

Tertiary medical center.

PATIENTS

Twenty-two infertile women with PCOS demonstrating premature luteinization during at least two consecutive CC cycles.

INTERVENTIONS

Randomized induction of ovulation either with FSH alone or with GnRH agonist combined with FSH for a single treatment cycle.

MAIN OUTCOME MEASURES

Premature luteinization was defined as serum progesterone >1.5 ng/mL before hCG administration.

RESULTS

Premature luteinization occurred in eight of the 10 patients (80%) in group A and in two of the 12 patients in group B (16.6%). This result corresponds to the higher mean (+/-SD) progesterone level present in group A patients as compared to those in group B (2.0 +/- 1.2 ng/mL vs. 1.2 +/- 0.6 ng/mL, P=0.03). No pregnancies were achieved in group A, whereas the pregnancy rate per cycle observed in group B was 33.3% (4/12). On the day of hCG administration, the maximum mean (+/-SD) estradiol level was significantly lower (P<0.0001) in group A (210.6 +/- 37.9 pg/mL) than in group B (600.3 +/- 253.8 pg/mL). The treatment duration and the number of FSH ampules used did not differ between the groups.

CONCLUSIONS

Pituitary desensitization with GnRH analog in combination with FSH is superior to FSH-only treatment in PCOS patients who demonstrate premature luteinization during CC treatment.