生长抑素类似物（奥曲肽）对大鼠实验性肝性脑病的作用。

Action of somatostatin analogue (octreotide) on experimental hepatic encephalopathy in rats.

作者信息

Kapicioglu S, Savaskan H, Ozdemir F, Baki A H, Kaynar K

机构信息

Karadeniz (Black Sea) Technical University, School of Medicine, Department of Internal Medicine, Trabzon, Turkey.

出版信息

Hepatogastroenterology. 2000 Jul-Aug;47(34):1060-2.

PMID:11020879

Abstract

BACKGROUND/AIMS: We investigated the effect of a somatostatin analogue (octreotide) on hepatic encephalopathy in a rat model. Fulminant hepatic failure was induced by thioacetamide twice daily for 3 consecutive days.

METHODOLOGY

Animals with hepatic encephalopathy grade III were divided into 2 groups. The groups received saline (control) or octreotide. In both groups the distance traveled in the open field activity, neurological score and mortality time were evaluated before and after the treatment.

RESULTS

In the control group the motor activity was 13.7 +/- 6.4 and 12.9 +/- 5.5 cm/10 min, the neurological score was 8.4 +/- 0.9 and 8.5 +/- 1.3 before and after the treatment, respectively. In the octreotide group the motor activity was 11.4 +/- 5.0 and 10.4 +/- 3.5 cm/10 min, the neurological score was 8.8 +/- 1.5 and 8.6 +/- 0.9 before and after the treatment, respectively. Mortality times in the saline and octreotide group were 76.1 +/- 28.1 and 89.7 +/- 46.5 min, respectively. All parameters of this study were statistically not significant.

CONCLUSIONS

This study demonstrated that somatostatin analogue, octreotide does not effect hepatic encephalopathy in an experimental rat model.

摘要

背景/目的：我们在大鼠模型中研究了一种生长抑素类似物（奥曲肽）对肝性脑病的影响。通过每天两次给予硫代乙酰胺，连续3天诱导暴发性肝衰竭。

方法

将III级肝性脑病的动物分为2组。两组分别接受生理盐水（对照组）或奥曲肽。在两组中，在治疗前后评估旷场活动中的行进距离、神经学评分和死亡时间。

结果

在对照组中，治疗前和治疗后的运动活动分别为13.7±6.4和12.9±5.5厘米/10分钟，神经学评分分别为8.4±0.9和8.5±1.3。在奥曲肽组中，治疗前和治疗后的运动活动分别为11.4±5.0和10.4±3.5厘米/10分钟，神经学评分分别为8.8±1.5和8.6±0.9。生理盐水组和奥曲肽组的死亡时间分别为76.1±28.1和89.7±46.5分钟。本研究的所有参数在统计学上均无显著意义。