Caramaschi P, Biasi D, Volpe A, Carletto A, Bambara L M
Dipartimento di Medicina Clinica e Sperimentale, Università, Verona.
Recenti Prog Med. 2000 Sep;91(9):436-40.
Buerger's disease or thromboangiitis obliterans is a disorder of unknown etiology which affects young heavy smokers, mainly of male sex; it is not clear why this disease afflicts only a little number of heavy smokers. Studies about genetic predisposition, autoimmune phenomena and platelet function have been performed in order to search additional etiologic factors without finding significant alterations. Recently some cases of Buerger's disease in association with hypercoagulable states have been described. The authors reported ten subjects affected by Buerger's disease, who have undergone to a clotting process evaluation. We have found 3 cases with fasting hyperhomocysteinemia in association with low level of plasma folate, 3 cases with high value of lipoprotein(a) (in 1 subject in association with IgG anticardiolipin antibody positivity), 1 case with IgM anticardiolipin antibody positivity. These findings, along with literature data, induce to hypothesize that hypercoagulable states may favour the clinical expression of Buerger's disease.
血栓闭塞性脉管炎或伯格氏病是一种病因不明的疾病，主要影响年轻的重度吸烟者，且男性居多；目前尚不清楚为何只有少数重度吸烟者会患上这种疾病。为了寻找其他病因，人们对遗传易感性、自身免疫现象和血小板功能进行了研究，但未发现明显异常。最近，有一些血栓闭塞性脉管炎与高凝状态相关的病例被报道。作者报告了10例患有血栓闭塞性脉管炎的患者，他们接受了凝血过程评估。我们发现3例空腹高同型半胱氨酸血症伴血浆叶酸水平低，3例脂蛋白(a)值高（其中1例伴有IgG抗心磷脂抗体阳性），1例IgM抗心磷脂抗体阳性。这些发现以及文献数据促使人们推测，高凝状态可能有利于血栓闭塞性脉管炎的临床表达。
