Mehta S B, Smith J M
Clin Allergy. 1975 Sep;5(3):279-84. doi: 10.1111/j.1365-2222.1975.tb01863.x.
A clinical trial of pre-seasonal hyposensitization with intra-nasal grass pollen extract was carried out in forty-two patients. Results were assessed subjectively, by clinical examination during the pollen season, and by measurements of nasal air flow. Useful relief of symptoms was considered to have occurred in fifteen out of twenty-one patients who had pre-seasonal treatment with pollen extract and in five out of twenty-one patients who had similar treatment with carbol saline as a placebo. Of twelve patients who were symptom free in the pollen season ten had nasal hyposensitization. It is concluded that this simple and safe method of treatment gives results comparable with those of pre-seasonal injections.
对42名患者进行了鼻内草花粉提取物季节性前减敏治疗的临床试验。通过花粉季节的临床检查和鼻气流测量进行主观结果评估。在接受花粉提取物季节性前治疗的21名患者中，有15名被认为症状得到有效缓解；在接受石炭酸生理盐水作为安慰剂进行类似治疗的21名患者中，有5名症状得到有效缓解。在花粉季节无症状的12名患者中，有10名出现了鼻减敏。得出的结论是，这种简单安全的治疗方法产生的结果与季节性前注射的结果相当。
