神经性厌食症中可逆性粒细胞杀伤缺陷
Reversible granulocyte killing defect in anorexia nervosa.
作者信息
Gotch F M, Spry C J, Mowat A G, Beeson P B, Maclennan I C
出版信息
Clin Exp Immunol. 1975 Aug;21(2):244-9.
Abstract
Three patients are described with anorexia nervosa in whom malnutrition was present with neutropenia and a granulocyte bactericidal degect. Their peripheral blood granulocytes were found to have a reduced rate of killing of Staphylococcus aureus and E. coli in vitro. The opsonic activity of the patients' sera towards Staphylococcus aureus was normal. One of these patients had recurrent episodes of infection which stopped after she had gained 13 kg in weight. Clinical recovery was associated with a return of granulocyte function to normal. It is concluded that granulocyte bactericidal capacity towards a variety of bacteria may be reduced in patients with anorexia nervosa who have malnutrition. This type of acquired granulocyte bactericidal deficiency appears to be reversible.
摘要
本文描述了三名神经性厌食症患者，他们存在营养不良，并伴有中性粒细胞减少和粒细胞杀菌缺陷。发现他们外周血中的粒细胞在体外对金黄色葡萄球菌和大肠杆菌的杀菌率降低。患者血清对金黄色葡萄球菌的调理活性正常。其中一名患者反复出现感染，在体重增加13公斤后感染停止。临床康复与粒细胞功能恢复正常有关。结论是，患有营养不良的神经性厌食症患者对多种细菌的粒细胞杀菌能力可能会降低。这种获得性粒细胞杀菌缺陷似乎是可逆的。
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