Martinon-Ego C, Berthier R
Laboratoire d'immunochimie, CEA-G, DBMS/ICH, INSERM U. 238, Université Joseph-Fourier, 17, rue des Martyrs, 38054 Grenoble cedex 9, France.
Ann Biol Clin (Paris). 2000 Sep-Oct;58(5):541-56.
Dendritic cells are critical initiators of immune responses. They not only activate pathogen-specific T and B lymphocytes, they also stimulate cells of the innate immune system. Furthermore, dentritic cells are involved in immunological tolerance induction through the elimination of autoreactive T lymphocytes. Over the last ten years, understanding of the development, biology and physiopathology of dentritic cells has progressed considerably which has lead to the use of dentritic cells in immunotherapy protocols to treat tumors, infections and auto-immune diseases.
树突状细胞是免疫反应的关键启动者。它们不仅激活病原体特异性的T和B淋巴细胞，还刺激先天免疫系统的细胞。此外，树突状细胞通过清除自身反应性T淋巴细胞参与免疫耐受的诱导。在过去十年中，对树突状细胞的发育、生物学和病理生理学的理解有了显著进展，这导致在免疫治疗方案中使用树突状细胞来治疗肿瘤、感染和自身免疫性疾病。
