Danilenko K V, Wirz-Justice A, Kräuchi K, Cajochen C, Weber J M, Fairhurst S, Terman M
Chronobiology and Sleep Laboratory, Psychiatric University Clinic, Basel, Switzerland.
Chronobiol Int. 2000 Sep;17(5):659-68. doi: 10.1081/cbi-100101072.
A specially designed apparatus that can simulate the waveform of the dawn or dusk signal at any latitude and any day of the year has been shown to phase shift the circadian pacemaker in rodents and primates at a fraction of the illuminance previously used. Until recently, it was considered that rather high illuminances or rather long exposure episodes to room light were necessary to phase shift human circadian rhythms. This experiment shows that, under controlled conditions of a modified constant routine protocol, a single dawn signal is sufficient to phase advance the timing of the onset of secretion of the pineal hormone melatonin. The significant phase advance of salivary melatonin of 20 minutes, which is enhanced to 34 minutes after three consecutive dawn signals, is small, but appears to be of sufficient magnitude to entrain the human circadian pacemaker, which has an endogenous period of about 24.2h.
一种经过特殊设计的仪器，能够在一年中的任何一天、任何纬度模拟黎明或黄昏信号的波形，该仪器已被证明可以在低于先前所用照度的情况下，使啮齿动物和灵长类动物的昼夜节律起搏器发生相位偏移。直到最近，人们还认为需要相当高的照度或相当长的室内光线照射时间才能使人类昼夜节律发生相位偏移。该实验表明，在改良的持续日常程序方案的受控条件下，单个黎明信号就足以使松果体激素褪黑素分泌开始的时间提前。唾液褪黑素显著提前20分钟，在连续三个黎明信号后提前至34分钟，虽然提前幅度较小，但似乎足以使具有约24.2小时内源性周期的人类昼夜节律起搏器发生同步。
