Häbler H J, Bartsch T, Jänig W
Physiologisches Institut, Christian-Albrechts-Universität, Kiel, Germany.
Auton Neurosci. 2000 Sep 1;83(1-2):75-80. doi: 10.1016/S0165-1838(00)00156-9.
It has been suggested that thermoregulatory stimulation changes respiration-related rhythmicity in the activity of postganglionic sympathetic neurones supplying the rat tail to a distinct modulation independent of respiration. To study this possibility, single and few fibre recordings were made from ten filaments split from the ventral collector nerves of the rat during whole body warming. Sympathetic activity was analysed by autocorrelation and phrenic-triggered summation. All neurones except one were gradually inhibited and lost their on-going activity above a core temperature of 39-39.5 degrees C while the frequency of the phrenic bursts increased significantly. During hyperthermia, all neurones tested exhibited a prominent respiratory modulation in their activity which, compared to normothermia, was significantly increased in strength, or even newly acquired. No other rhythm emerged. These results speak against the hypothesis that in the rat sympathetic pathways controlling the tail vasculature and thus involved in thermoregulation, during hyperthermia become controlled by central oscillators distinct from the respiratory rhythm generator. Rather, respiratory modulation appears to remain the dominant rhythm as is common for sympathetic neurones supplying other cardiovascular targets.
有人提出，体温调节刺激会将支配大鼠尾巴的节后交感神经元活动中与呼吸相关的节律性转变为一种独立于呼吸的独特调节。为了研究这种可能性，在全身升温过程中，从大鼠腹侧收集神经分离出的10根细丝上进行了单纤维和少数纤维记录。通过自相关和膈神经触发总和分析交感神经活动。除一个神经元外，所有神经元在核心温度高于39 - 39.5摄氏度时逐渐受到抑制并失去其持续活动，而膈神经冲动的频率显著增加。在体温过高期间，所有测试的神经元在其活动中都表现出明显的呼吸调节，与正常体温相比，其强度显著增加，甚至是新获得的。没有出现其他节律。这些结果与以下假设相悖：在大鼠中，控制尾巴血管系统并因此参与体温调节的交感神经通路，在体温过高时由不同于呼吸节律发生器的中枢振荡器控制。相反，呼吸调节似乎仍然是主导节律，这对于供应其他心血管目标的交感神经元来说是常见的。
