延髓头端中缝神经元的抑制可阻止冷刺激引起的大鼠尾部和兔耳动脉交感神经的活动。
Inhibition of rostral medullary raphé neurons prevents cold-induced activity in sympathetic nerves to rat tail and rabbit ear arteries.
作者信息
Ootsuka Youichirou, Blessing William W, McAllen Robin M
机构信息
Department of Human Physiology, School of Medicine, Centre for Neuroscience, Flinders University, Bedford Park, SA 5042, Australia.
出版信息
Neurosci Lett. 2004 Feb 26;357(1):58-62. doi: 10.1016/j.neulet.2003.11.067.
Sympathetically-mediated vasoconstriction of cutaneous vessels is critical for thermoregulation in the cold. We determined whether cold-induced sympathetic discharge depends on activity of neurons in the rostral medullary raphé. In urethane-anesthetized rats and rabbits, cooling the trunk skin by a water jacket reproducibly increased cutaneous sympathetic discharge recorded in the tail (rats) and the ear pinna (rabbits). When neurons in the rostral medullary raphé were inhibited by microinjection of glycine (30-100 nmol in 60-200 nl in rats), or muscimol (1 nmol in 100 nl in rabbits), cutaneous sympathetic activity was silenced and no longer responded to cooling (7+/-3 and 5+/-2% of pre-injection increase in rats and rabbits, respectively, P < 0.01). Our data demonstrate that activity of rostral medullary raphé neurons is important for the CNS mediation of cold-induced increases in sympathetic cutaneous vasomotor nerves.
交感神经介导的皮肤血管收缩对于寒冷环境下的体温调节至关重要。我们确定了冷诱导的交感神经放电是否依赖于延髓头端中缝核神经元的活动。在氨基甲酸乙酯麻醉的大鼠和兔子中，用水套冷却躯干皮肤可重复性地增加在尾巴（大鼠）和耳廓（兔子）记录到的皮肤交感神经放电。当通过微量注射甘氨酸（大鼠中60 - 200 nl含30 - 100 nmol）或蝇蕈醇（兔子中100 nl含1 nmol）抑制延髓头端中缝核的神经元时，皮肤交感神经活动被消除，并且不再对冷却产生反应（大鼠和兔子分别为注射前增加量的7±3%和5±2%，P < 0.01）。我们的数据表明，延髓头端中缝核神经元的活动对于中枢神经系统介导冷诱导的皮肤交感血管运动神经增加很重要。
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