Aboudy Y, Barnea B, Yosef L, Frank T, Mendelson E
Central Virology Laboratory, Public Health Services, Ministry of Health and The Chaim Sheba Medical Center, Tel-Hashomer, 52621, Israel.
J Infect. 2000 Sep;41(2):187-9. doi: 10.1053/jinf.2000.0716.
We report a documented case of clinically apparent rubella reinfection during pregnancy with rubelliform rash and fever followed by lymphodenopathy at the 18th week of gestation, in a previously vaccinated woman with haemagglutination inhibition (HI) antibody titre of 1:32. The serological tests results (including neutralizing antibodies) demonstrated a significant rise in her rubella specific IgG level with strongly positive IgM reactivity. In addition, rubella-specific IgG antibody avidity testing displayed high avidity index (53-88%) typical of rubella reinfection. Umbilical cord blood, drawn by sonographic-guided cordocentesis at 24 weeks' gestation, was found to be negative for rubella-specific IgM antibody. The pregnancy was continued to term, and a healthy infant was born.
我们报告了一例有记录的病例，一名曾接种疫苗、血凝抑制（HI）抗体滴度为1:32的女性在孕期发生了临床明显的风疹再感染，妊娠18周时出现风疹样皮疹和发热，随后出现淋巴结病。血清学检测结果（包括中和抗体）显示她的风疹特异性IgG水平显著升高，IgM反应呈强阳性。此外，风疹特异性IgG抗体亲和力检测显示出风疹再感染典型的高亲和力指数（53 - 88%）。在妊娠24周时通过超声引导下脐带穿刺采集的脐带血风疹特异性IgM抗体检测为阴性。妊娠持续至足月，产下一名健康婴儿。
