Funahashi H, Hori T, Shimoda Y, Mizushima H, Ryushi T, Katoh S, Shioda S
Department of Anatomy, Showa University School of Medicine, 142-8555, Tokyo, Japan.
Regul Pept. 2000 Aug 25;92(1-3):31-5. doi: 10.1016/s0167-0115(00)00146-4.
Both leptin and orexin have been recently discovered as peptides involved in feeding regulation. The morphological evidence of neural interaction between leptin and orexin, one considered to inhibit food intake and the other to stimulate it in the central nervous system (CNS), was studied by use of double immunostaining method. The leptin receptor-like immunoreactive (LR-LI) neurons in the hypothalamic arcuate nucleus and ventromedial nucleus were innervated by orexin-like immunoreactive (OX-LI) neurons. The distribution of LR-LI neurons in the hypothalamus was very similar to that of OX-LI neurons. These results may suggest that leptin and orexin are intimately correlated with each other and that they reciprocally regulate feeding at the hypothalamic level.
瘦素和食欲肽最近都被发现是参与进食调节的肽类物质。通过使用双重免疫染色法，研究了瘦素和食欲肽在中枢神经系统（CNS）中神经相互作用的形态学证据，其中一种被认为抑制食物摄入，另一种则刺激食物摄入。下丘脑弓状核和腹内侧核中的瘦素受体样免疫反应性（LR-LI）神经元接受食欲肽样免疫反应性（OX-LI）神经元的支配。下丘脑LR-LI神经元的分布与OX-LI神经元的分布非常相似。这些结果可能表明瘦素和食欲肽相互密切相关，并且它们在下丘脑水平上相互调节进食。
