青春期前和青春期儿童在促黄体生成素释放激素刺激下的血浆促性腺激素（促黄体生成素和促卵泡生成素）浓度。

Plasma gonadotropin (LH and FSH) concentrations in repubertal and pubertal children upon stimulation by LH-releasing hormone.

作者信息

Lovrencić M K, Banovac Z R, Oberiter V, Sekso M, Petek M, Skrabalo L K, Resetić J

出版信息

Helv Paediatr Acta. 1975 Oct;30(3):232-8.

Abstract

The simultaneous determination of LH and FSH were carried out in a single plasma sample by double antibody radioimmunoassays in a total of 26 prepubertal and pubertal children. The blood samples were taken before and after i.v. application of 25 mug synthetic LH-RH. Plasma LH and FSH concentrations found in prepubertal boys and girls at beginning of the test and at the time of maximum response were compared with those measured in pubertal boys and girls. The mean basal levels of LH and FSH are in group I (8 prepubertal girls): LH 0.6+/-0.7 (SD) mIU/ml, FSH 1.5+/-0.8 mIU/ml; in group II (6 prepubertal boys): LH 1.8+/-1.0 mIU/ml, FSH 2.0+/-0.8 mIU/ml; in group III (6 pubertal girls): LH 4.1+/-2.0 mIU/ml, FSH 4.7+/-2.8 mIU/ml; in group IV (6 pubertal boys): LH 3.5+/-2.3 mIU/ml, FSH2.0+/-1.2 mIU/ml. The mean maximum response of LH and FSH after stimulation are in group I: LH 4.1+/-2.3 mIU/ml, FSH 11.7+/-3.7 mIU/ml; in group II: LH 4.2+/-1.0 mIU/ml, FSH 6.0+/-1.1 mIU/ml; in group III: LH 19.7+/-10.6 mIU/ml, FSH 12.8+/-5.7 mIU/ml; in group IV: LH 13.4+/-5.7 mIU/ml, FSH 3.8+/-0.9 mIU/ml. It is suggested that without stimulation of the pituitary with LH-RH, plasma LH and FSH levels are not reliable parameters to test the pituitary gonadotropin reserve.

摘要

采用双抗体放射免疫分析法，对26名青春期前和青春期儿童的单个血浆样本同时进行促黄体生成素（LH）和促卵泡生成素（FSH）的测定。静脉注射25微克合成促黄体生成素释放激素（LH-RH）前后采集血样。将青春期前男孩和女孩在测试开始时以及最大反应时的血浆LH和FSH浓度与青春期男孩和女孩测得的浓度进行比较。LH和FSH的平均基础水平在第一组（8名青春期前女孩）中：LH为0.6±0.7（标准差）mIU/ml，FSH为1.5±0.8 mIU/ml；在第二组（6名青春期前男孩）中：LH为1.8±1.0 mIU/ml，FSH为2.0±0.8 mIU/ml；在第三组（6名青春期女孩）中：LH为4.1±2.0 mIU/ml，FSH为4.7±2.8 mIU/ml；在第四组（6名青春期男孩）中：LH为3.5±2.3 mIU/ml，FSH为2.0±1.2 mIU/ml。刺激后LH和FSH的平均最大反应在第一组中：LH为4.1±2.3 mIU/ml，FSH为11.7±3.7 mIU/ml；在第二组中：LH为4.2±1.0 mIU/ml，FSH为6.0±1.1 mIU/ml；在第三组中：LH为19.7±10.6 mIU/ml，FSH为12.8±5.7 mIU/ml；在第四组中：LH为13.4±5.7 mIU/ml，FSH为3.8±0.9 mIU/ml。研究表明，在未用LH-RH刺激垂体的情况下，血浆LH和FSH水平并非检测垂体促性腺激素储备的可靠指标。