Bairey Merz C N, Olson M, McGorray S, Pakstis D L, Zell K, Rickens C R, Kelsey S F, Bittner V, Sharaf B L, Sopko G
Division of Cardiology, Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Pittsburgh, Pennsylvania, USA.
J Womens Health Gend Based Med. 2000 Sep;9(7):769-77. doi: 10.1089/15246090050147745.
Physical activity and functional capacity have not been assessed by questionnaire for criterion validity in women. We wished to evaluate the ability of a physical activity and a functional capacity assessment questionnaire to predict functional capacity measured by treadmill exercise stress testing, as well as correlate with cardiac risk factors and angiographic coronary artery disease (CAD) in women. In a National Heart, Lung and Blood Institute (NHLBI)-sponsored cross-sectional population study involving four academic medical centers, 476 women with cardiac risk factors undergoing coronary angiography for evaluation for suspected myocardial ischemia were enrolled in the Women's Ischemia Syndrome Evaluation (WISE). The main outcome measures were functional capacity measured during symptom-limited exercise treadmill testing, cardiac risk factors, and CAD, using core laboratory-determined measures. Physical activity measured by the Postmenopausal Estrogen and Progesterone Intervention physical activity questionnaire (PEPI-Q) and functional capacity measured by the Duke Activity Status Index (DASI) questionnaire, correlated with functional capacity measured in metabolic equivalents (METS), as estimated during symptom-limited exercise treadmill testing (r = 0.27, p = 0.001 and r = 0.31, p = 0. 0002, respectively). The DASI was a significant independent predictor of functional capacity even after adjustment for cardiac risk factors, and the PEPI-Q was not. The DASI and PEPI-Q scores were inversely associated with higher numbers and levels of cardiac risk factors, as well as angiographic CAD. The DASI questionnaire is a reasonable correlate of functional capacity achieved during symptom-limited treadmill exercise testing in women with suspected myocardial ischemia. Lower functional capacity or physical activity measured by the DASI and PEPI-Q, respectively, is associated with more prevalent cardiac risk factors and angiographic CAD. These findings suggest that the DASI and, to a lesser extent, the PEPI-Q have criterion validity for use in health-related research in women.
尚未通过问卷调查评估身体活动和功能能力在女性中的标准效度。我们希望评估一份身体活动和功能能力评估问卷预测通过跑步机运动应激试验测量的功能能力的能力，以及与女性心脏危险因素和血管造影冠状动脉疾病（CAD）的相关性。在一项由美国国立心肺血液研究所（NHLBI）赞助的涉及四个学术医疗中心的横断面人群研究中，476名有心脏危险因素且因疑似心肌缺血接受冠状动脉造影评估的女性被纳入女性缺血综合征评估（WISE）研究。主要结局指标是在症状限制运动跑步机测试期间测量的功能能力、心脏危险因素和CAD，采用核心实验室确定的测量方法。通过绝经后雌激素和孕激素干预身体活动问卷（PEPI-Q）测量的身体活动以及通过杜克活动状态指数（DASI）问卷测量的功能能力，与症状限制运动跑步机测试期间估计的以代谢当量（METS）衡量的功能能力相关（分别为r = 0.27，p = 0.001和r = 0.31，p = 0.0002）。即使在调整心脏危险因素后，DASI仍是功能能力的显著独立预测因子，而PEPI-Q不是。DASI和PEPI-Q评分与更多数量和更高水平的心脏危险因素以及血管造影CAD呈负相关。DASI问卷与疑似心肌缺血女性在症状限制跑步机运动测试期间达到的功能能力有合理的相关性。分别通过DASI和PEPI-Q测量的较低功能能力或身体活动与更普遍的心脏危险因素和血管造影CAD相关。这些发现表明，DASI以及在较小程度上PEPI-Q在女性健康相关研究中具有标准效度。
