Granowitz E V, Tabor K J, Kirchhoffer J B
Department of Medicine, Baystate Medical Center, Springfield, Massachusetts 01199, USA.
Pacing Clin Electrophysiol. 2000 Sep;23(9):1433-5. doi: 10.1111/j.1540-8159.2000.tb00976.x.
A patient on disopyramide developed disopyramide toxicity when treated concurrently with azithromycin. Evidence of toxicity included an elevated serum disopyramide level and ventricular tachycardia requiring cardioversion. The azalide antibiotic presumably inhibited dealkylation of disopyramide to its major metabolite, mono-N-dealkyldisopyramide. Physicians should avoid using azithromycin in patients on disopyramide. If this drug combination is unavoidable, disopyramide levels must be closely monitored.
一名服用丙吡胺的患者在与阿奇霉素同时治疗时发生了丙吡胺中毒。中毒证据包括血清丙吡胺水平升高以及需要进行心脏复律的室性心动过速。这种氮杂内酯类抗生素可能抑制了丙吡胺脱烷基生成其主要代谢产物单 -N-去烷基丙吡胺。医生应避免在服用丙吡胺的患者中使用阿奇霉素。如果这种药物组合不可避免，必须密切监测丙吡胺水平。
