Steere A C, Aber R C, Warford L R, Murphy K E, Feeley J C, Hayes P S, Wilkinson H W, Facklam R R
J Pediatr. 1975 Nov;87(5):784-7. doi: 10.1016/s0022-3476(75)80311-8.
Within a six-day period in March, 1974, three infants born at a hospital in central Arkansas developed meningitis caused by group B, type III Streptococci. Three factors suggested nosocomial transmission of the organism in the nursery: (1) the three infants were born in a six-day period, (2) four weeks after their infants' births, none of the parents had positive cultures for group B streptococci, and (3) 31% of infants born in the hospital in March were colonized with group B, type III streptococci, while in April, after control measures in the nursery were instituted, only 2% of infants were colonized with this type (p less than 0.0002). Colonized infants were treated with penicillin, but follow-up cultures at two and six weeks showed that half the infants tested were still colonized. The number of personnel colonized with group B streptococci was not significantly different in personnel exposed to infants when compared with those that were not, and handwashing and environmental cultures were negative for group B streptococci. The results of this investigation give additional support to the concept that nosocomial transmission of group B streptococci can occur and may be effectively interrupted by control measures in the nursery.
1974年3月的六天时间里，阿肯色州中部一家医院出生的三名婴儿患上了由B族III型链球菌引起的脑膜炎。有三个因素表明该病菌在托儿所发生了医院内传播：（1）这三名婴儿在六天内出生；（2）在其婴儿出生四周后，没有一位家长的B族链球菌培养呈阳性；（3）3月份在该医院出生的婴儿中有31%被B族III型链球菌定植，而在4月份，托儿所采取控制措施后，只有2%的婴儿被该型病菌定植（p小于0.0002）。对被定植的婴儿使用青霉素进行治疗，但在两周和六周时的后续培养显示，接受检测的婴儿中有一半仍被定植。与未接触婴儿的人员相比，接触婴儿的人员中被B族链球菌定植的人数没有显著差异，并且洗手和环境培养中B族链球菌均为阴性。这项调查结果进一步支持了以下观点：B族链球菌可发生医院内传播，且托儿所的控制措施可能有效阻断这种传播。
